Results 131 to 140 of about 3,252,859 (280)
Enhancing Covid-19 Decision-Making by Creating an Assurance Case for Simulation Models
, 2020 Simulation models have been informing the COVID-19 policy-making process. These models, therefore, have significant influence on risk of societal harms.
Alexander, Rob +6 more
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Biblical Scriptures impact on six ethical models influencing accounting practices. [PDF]
The recent frauds in organizations have been a point for reflection among researchers and practitioners regarding the lack of morality in certain decision-making.
Gago Rodríguez, Susana +1 more
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
BARRIERS IN THE MATHEMATICAL MODELLING OF DECISION-MAKING [PDF]
Decision-making is becoming increasingly complex as the number of stakeholders rises,the number of decision-makers rises as well, the implications to consider are various and far-reaching,risks and uncertainties abound and the regulatory framework is ...
Popescu Oana
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Fusion collaboration in global teams. [PDF]
This essay introduces a new model for facilitating collaboration in global teams that leads to creatively realistic solutions to global problems. The conceptualization for the fusion model of global team collaboration draws on the culinary tradition of ...
Brett, JM, Janssens, Maddy
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source