Results 121 to 130 of about 23,272 (250)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Entrepreneurs` Cognitive and Decision Making Styles

, 2015
The main purpose of this study is to explore the relation between decision-making styles which are measured by the General decision-making style (GDMS) test and information processing styles which are often termed cognitive styles and are, in this study,
Mahmoud Motvaseli, Fariba Lotfizadeh
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Entrepreneurs` Cognitive and Decision Making Styles

, 2016
The main purpose of this study is to explore the relation between decision-making styles which are measured by the General decision-making style (GDMS) test and information processing styles which are often termed cognitive styles and are, in this study,
Mahmoud Motvaseli; Department of Entrepreneurship, Tehran University, Tehran, Iran, Fariba Lotfizadeh; Department of Entrepreneurship, Tehran University, Tehran, Iran   +1 more
core  

Decision-Making Styles as Predictors of Career Decision Difficulties in Secondary School Students with Regard to Gender

Psychological Topics, 2019
The study aimed to examine whether students' different career decision styles predict their difficulties in deciding about their future education. We measured students' adaptive self-confident and three maladaptive decision-making styles: avoidant, panic,
Sonja Pečjak, Anja Podlesek, Tina Pirc
doaj   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Mindfulness and Decision Making: A Study on Wrestling Referees

Sportif Bakış Spor ve Eğitim Bilimleri Dergisi
This study was conducted to examine the relationship between mindfulness levels and decision making styles of wrestling referees. Since referees have to make instant decisions during the competition, the effect of their individual cognitive processes on
Mustafa Vural, Gokhan Bayraktar
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the Relationship between Decision-Making Styles and Emotion Regulation: A Study of Police Officials in Portuguese Public Security

Social Sciences
In public security policing, where pressure is constant, effective decision-making and emotion regulation are critical, especially for leaders. These processes significantly impact upon work results, performance, officials’ health, employee well-being ...
Carla Carvalho, Ana Pinto, Beatriz Pinedo, Soraia Oliveira, Sonia Maria Guedes Gondim, Mary Sandra Carlotto, Rui Coelho de Moura   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source