Results 81 to 90 of about 709,268 (298)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Monte-Carlo tree search for persona based player modeling [PDF]

, 2015
Is it possible to conduct player modeling without any players? In this paper we use Monte-Carlo Tree Search-controlled procedural personas to simulate a range of decision making styles in the puzzle game MiniDungeons 2.
Eleventh AAAI Conference on Artificial Intelligence and Interactive Digital Environment, Holmgard, Christoffer, Liapis, Antonios, Togelius, Julian, Yannakakis, Georgios N.   +4 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Correlation between Thinking Styles with Clinical Decision Making among Nurses Working in Educational Hospitals Affiliated to Tabriz University of Medical Sciences

Preventive Care in Nursing and Midwifery Journal, 2014
Background and Objectives: Considering the importance of thinking styles in individualschr('39') decision making, this study was conducted to investigate the correlation between thinking styles with clinical decision making among nurses working in ...
Elmira Hassanpour, Nadereh Naderi ravesh, Zahra Safavi Bayat, Malihe Nasiri, Kianoush Niroumand Zandi   +4 more
doaj  

Analyzing the Decision-Making Styles of Customers to Buy Sports Equipment [PDF]

Research in Sport Management and Marketing
Purpose: Customers use different decision making styles to buy sports equipment. The purpose of this research is to analyze the decision-making styles of customers for buy sports equipment.Methods: In this research, cross-sectional survey method was used
Jalil Pourzarnegar
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Antecedents of Effective Decision Making: A Cognitive Approach [PDF]

Decision-making effectiveness has been associated with how well managers adapt their cognitive style to task requirements. In this paper, theories regarding decision-making under uncertainty and the use of judgment and intuition are reviewed and ...
Lemmink,Jos, Ouwersloot,Hans, Riel,Allard C.R.,van   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Relevance of Context to Decision-Making Styles [PDF]

, 2008
This study examined two different realms of regret, economic and relationship. Measures of regret were correlated in the two realms with self-efficacy, gender, and decision making styles (intuitive, analytical, regret-avoidant).
Evans, Clarisse
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source