Results 141 to 150 of about 354,100 (264)

Development and acceptability of a patient decision aid for people with degenerative cervical myelopathy: an international mixed-methods study. [PDF]

BMJ Open
Gamble AR, Anderson DB, McKay MJ, Davies B, Macpherson S, Van Gelder J, Hoffmann T, McCaffery K, Stevens SX, Ammendolia C, Chauhan RV, Zipser CM, Boerger TF, Tetreault LA, Fehlings MG, Dustan E, Nugent C, Holmgren H, Demetriades AK, Lantz JM, Dhillon R, Maher CG, Zadro JR.   +22 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Interactive, Personalized Patient Decision Aid for COVID-19 Vaccination in Canada: User-Centered Design Approach. [PDF]

JMIR Hum Factors
Etienne D, Archambault PM, Bogoch II, Chambers CT, Chittle AD, Demers J, Driedger SM, Dubé È, Gagnon MP, Gavaruzzi T, Giguère A, Grandvaux N, Grindrod K, Hakim H, Jeimy S, Kindrachuk J, LeBlanc A, MacDonald SE, Ndjaboue R, Noubi M, Orji R, Paquette JS, Parent E, Renaud JS, Sander B, Taljaard M, Tannenbaum Greenberg D, Tremblay MC, Vohra-Miller S, Welch VA, Witteman HO.   +30 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Digital Patient Decision Aid for Antiobesity Medications: Mixed Methods Study of Human-Centered Design and Usability Evaluation. [PDF]

J Med Internet Res
Wang LJ, Wang YJ, Cheng YL, Fang WL, Wang W, Zheng MC.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Japanese Encephalitis Vaccine Decision Aid for Travelers: A Randomized Clinical Trial.

JAMA Netw Open
McGuinness SL, Eades O, Morris J, Seale H, Cheng AC, Leder K.   +5 more
europepmc   +1 more source

Evaluating a digital decision aid for atrial fibrillation rhythm control in a hybrid implementation-effectiveness trial. [PDF]

NPJ Digit Med
Reading Turchioe M, Shamnath A, Slotwiner D, Zhao Y, Saluja D, Goldbarg S, Kim J, Varosy P, Biviano A.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

My Heart and CKD: Pathway to Implementing a Decision Aid for Patients With CKD and Coronary Artery Disease. [PDF]

Can J Kidney Health Dis
Babione JN, Javaheri P, Kruger D, Wilson T, Pearson W, Loth M, March V, Gerber W, Har BJ, Graham MM, Wilton SB, Lewis KB, James MT.   +12 more
europepmc   +1 more source