Results 91 to 100 of about 357,721 (279)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Graphical representation of global water models [PDF]

Geoscientific Model Development
Numerical models are simplified representations of the real world at a finite level of complexity. Global water models are used to simulate the terrestrial part of the global water cycle, and their outputs contribute to the evaluation of important ...
H. Müller Schmied, H. Müller Schmied, S. N. Gosling, M. Garnsworthy, L. Müller, C.-E. Telteu, A. K. Ahmed, L. S. Andersen, J. Boulange, P. Burek, J. Chang, H. Chen, L. Gudmundsson, M. Grillakis, L. Guillaumot, N. Hanasaki, A. Koutroulis, R. Kumar, G. Leng, J. Liu, J. Liu, J. Liu, X. Liu, I. Menke, I. Menke, V. Mishra, V. Mishra, Y. Pokhrel, O. Rakovec, O. Rakovec, L. Samaniego, L. Samaniego, Y. Satoh, H. L. Shah, M. Smilovic, T. Stacke, E. Sutanudjaja, W. Thiery, A. Tsilimigkras, Y. Wada, N. Wanders, T. Yokohata   +41 more
doaj   +1 more source

Paradata and Bayesian networks: a tool for monitoring and troubleshooting the data production process [PDF]

The problem of monitoring and managing the data production process by means of process flow indicators is presented in a decision theory framework. Here it is shown how to represent and solve the decision problem via influence diagrams, i.e.
Marco Ballin, Mauro Scanu, Paola Vicard
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Reconstruction of the transformer theory

MATEC Web of Conferences, 2018
The fallacy of the traditional transformer theory is illustrated. The fundamentals of the new theory, beginning from principle of the transformer action, motion of electromagnetic field in its window, new equivalent circuit and vector diagrams are ...
Shakirov Mansur
doaj   +1 more source

Decision diagrams in machine learning: an empirical study on real-life credit-risk data. [PDF]

Decision trees are a widely used knowledge representation in machine learning. However, one of their main drawbacks is the inherent replication of isomorphic subtrees, as a result of which the produced classifiers might become too large to be ...
Baesens, Bart, Files, CM, Mues, Christophe, Vanthienen, Jan   +3 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Complexity of XOR/XNOR boolean functions: a model using binary decision diagrams and back propagation neural networks

Journal of Computer Science and Technology, 2007
This paper proposes a model that predicts the complexity of Boolean functions with only XOR/XNOR min-terms using back propagation neural networks (BPNNs) applied to Binary Decision Diagrams (BDDs). The BPNN model (BPNNM) is developed through the training
Ali Assi, P. W. C. Prasad, Azam Beg, V. C. Prasad   +3 more
doaj  

The application of graphical representations in estimation of probabilistic events

Ricerche di Pedagogia e Didattica, 2014
The communication of uncertain and certain information is essential for individual behaviour and decision making. But many subjects have difficulty in understanding uncertainty-related problems.
Mirian Agus, Maria Pietronilla Penna, Maribel Peró-Cebollero, Joan Guàrdia-Olmos, Eliano Pessa   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source