Results 111 to 120 of about 9,040,288 (288)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Impact of computer-based treatment planning software on clinical judgment of dental students for planning prosthodontic rehabilitation

Advances in Medical Education and Practice, 2014
Saee Deshpande, Jayashree Chahande Department of Prosthodontics, Vidya Shikshan Prasarak Mandal's (VPSM) Dental College and Research Centre, Nagpur, Maharashtra, India Purpose: Successful prosthodontic rehabilitation involves making many ...
Deshpande S, Chahande J
doaj  

Comparison of the ABC/2 formula with computer-assisted volumetry of ischemic cerebellar stroke.

PLoS ONE
IntroductionCurrent guidelines suggest surgical decompression for ischemic cerebellar stroke in case of significant mass effect. Recent research has aimed to identify a possible threshold for mass effect.
Milos Arsenovic, Artem Rafaelian, Daniel Dubinski, Daniel Cantré, Eva Herrmann, Bedjan Behmanesh, Svorad Trnovec, Thomas M Freiman, Marc-André Weber, Matthias Wittstock, Florian Gessler, Sae-Yeon Won   +11 more
doaj   +1 more source

Oral mucosal lesions triage via YOLOv7 models

Journal of the Formosan Medical Association
Background/purpose: The global incidence of lip and oral cavity cancer continues to rise, necessitating improved early detection methods. This study leverages the capabilities of computer vision and deep learning to enhance the early detection and ...
Yu Hsu, Cheng-Ying Chou, Yu-Cheng Huang, Yu-Chieh Liu, Yong-Long Lin, Zi-Ping Zhong, Jun-Kai Liao, Jun-Ching Lee, Hsin-Yu Chen, Jang-Jaer Lee, Shyh-Jye Chen   +10 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Accuracy and Precision in Computer-Assisted Methods for Orthopaedic Surgery

, 2015
This chapter reviews the major approaches to the definition of bone cutting accuracy in the field of computer-assisted orthopaedic surgery. The first part of the chapter reviews the different concepts of accuracy found in literature, from localization in
Federico E. Milano, Cartiaux, Olivier, Milano, Federico, Olivier Cartiaux   +3 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Digital Health Technology & Cancer Care: Conceptual Framework Leading Comprehensive Fruitfulness

Journal of Healthcare Leadership
Sunil Jain,1,* Prem Kamal Jain,2,* Ashok Kumar Puranik3,4,* 1Armed Forces Medical Services, India; 2Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India; 3AIIMS, Guwahati, India; 4Alfred ...
Jain S, Jain PK, Puranik AK
doaj