Results 91 to 100 of about 433,654 (311)

Shared decision making interventions for people with mental health conditions [PDF]

, 2010
Background: One person in every four will suffer from a diagnosable mental health condition during their life course. Such conditions can have a devastating impact on the lives of the individual, their family and society.
Hagen, Suzanne, Hagen, Suzanne; id_orcid, Duncan, Edward, Best, Catherine   +3 more
core   +1 more source

Encounter-based randomization did not result in contamination in a shared decision-making trial: a secondary analysis

, 2022
Objectives: To estimate the level of contamination in an encounter-randomized trial evaluating a shared decision-making (SDM) tool. Study Design and Setting: We assessed contamination at three levels: (1) tool contamination (whether the tool was ...
Bellolio, F., Branda, M.E., Burnett, B., Montori, V.M., Shared Decision-Making Atrial Fibr, Spencer-Bonilla, G., Guyatt, G., Kunneman, M.   +7 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Empowering women considering reconstructive breast surgery – a Danish cohort study on decisional conflict and regret

Journal of Plastic Surgery and Hand Surgery
Backround: Breast reconstructive surgery following mastectomy or lumpectomy presents a significant decisional challenge for patients. The emotional weight of a cancer diagnosis and the complexity of surgical options necessitate a comprehensive support ...
Bekka Christensen, Karina Steffensen, Anna Mejldal, Vibeke Koudahl   +3 more
doaj   +1 more source

Better Decision-Making: Shared Mental Models and the Clinical Competency Committee. [PDF]

J Grad Med Educ, 2021
Edgar L, Jones MD, Harsy B, Passiment M, Hauer KE.   +4 more
europepmc   +1 more source

The role of shared leadership in the decision making processes of new technology based firms

, 2013
The dynamic business environment is seen by many as requiring a significant change in our thinking about leadership. Shared leadership is one alternative to the 'classic' vertical model and implies that either no individual performs all of the leadership
Higgs, Malcolm, Patton, Dean, Higgs, M.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Can Streamlined Multicriteria Decision Analysis Be Used to Implement Shared Decision Making for Colorectal Cancer Screening?

, 2013
BACKGROUND: Current US colorectal cancer screening guidelines that call for shared decision making regarding the choice among several recommended screening options are difficult to implement.
Dolan, James G., Imperiale, Thomas F., Allison, Jeroan J., Boohaker, Emily, Allison, Jeroan   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source