Results 81 to 90 of about 7,090,393 (298)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Exploration of between-hospital variation and the basis for decision making in management of malignant colorectal polyps- a Danish population-based study

World Journal of Surgical Oncology
Background Finding an unexpected carcinoma in an endoscopically resected colorectal polyp poses a dilemma regarding the subsequent management strategy. Proceeding to surgery with formal segmental bowel resection is associated with a low recurrence risk ...
Helene Juul Würtz, Lea Lund, Jan Lindebjerg, Karina Dahl Steffensen, Adrian Edwards, Hans B. Rahr   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The very idea of shared decision-making: views from social science [PDF]

, 2003
Aim: To examine the ‘idea of shared decision making focusing on assumptions about the concepts ‘choice’ and ‘decision making’;\ud \ud Content: Much of the research literature on shared decision making relies on a prioi assumptions about concepts of ...
Hepworth, Julie, Murtagh, M.J., Rapley, Timothy   +2 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Better Decision-Making: Shared Mental Models and the Clinical Competency Committee. [PDF]

J Grad Med Educ, 2021
Edgar L, Jones MD, Harsy B, Passiment M, Hauer KE.   +4 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Validation of Pre-Adolescent Decision-Making Competence in Turkish students

, 2019
The objective of this study was to adapt the Pre-Adolescent Decision-Making Competence Test to Turkish, which was originally developed in English by Weller, Levin, Rose and Bossard (2012) for assessing decision-making competence of children between the ...
Cevik, Yasemin Demiraslan and Dogan, Nuri and Daghan, Gokhan and Mumcu, Filiz Kuskaya and Somyurek, Sibel and Karaman, Haydar
core  

Empowering women considering reconstructive breast surgery – a Danish cohort study on decisional conflict and regret

Journal of Plastic Surgery and Hand Surgery
Backround: Breast reconstructive surgery following mastectomy or lumpectomy presents a significant decisional challenge for patients. The emotional weight of a cancer diagnosis and the complexity of surgical options necessitate a comprehensive support ...
Bekka Christensen, Karina Steffensen, Anna Mejldal, Vibeke Koudahl   +3 more
doaj   +1 more source