Results 131 to 140 of about 12,156,070 (400)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Fratricide: defective decision making

open access: yes, 2009
Motivation – to explore the applicability of a Human Factors methodology for the investigation of fratricide. Research approach – The EAST methodology was used to analyse an incident of fratricide and its ability to explore the Famous Five of Fratricide (
Rafferty, Laura A.   +2 more
core  

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Making a Decision on Ethical Decision-Making Models

open access: yes, 2020
Those in the helping professions, like psychology, counseling, and social work, have numerous ethical guidelines and codes to dictate ethical behavior. These codes, while extensive, do not encompass all situations. When professionals find themselves in an ambiguous situation, it is called an ethical dilemma.
openaire   +3 more sources

THE EVIDENCE FOR A DECISION-MAKING THEORY OF VISUAL DETECTION [PDF]

open access: green, 1955
John A. Swets   +3 more
openalex   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Effectiveness of an object moving depending on its orientation in the environment: a kinematic analysis of motor planning and execution

open access: yesНервно-мышечные болезни
Background. Grasping objects with the hand is one of the most common movements in everyday life. It requires training involving the cognitive processes of goal selection and motor planning.Aim.
A. O. Vyazmin   +5 more
doaj   +1 more source

Transcranial magnetic stimulation with electroencephalography: methodology, applications for research and cilinics

open access: yesНервно-мышечные болезни, 2018
Combined use of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is a highly informative cutting edge technology which is relevant for fundamental, clinical and  translational research. Unique capabilities of TMS-EEG approach  allow
M. A. Nazarova   +3 more
doaj   +1 more source

D numbers theory based game-theoretic framework in adversarial decision making under fuzzy environment [PDF]

open access: yesarXiv, 2017
Adversarial decision making is a particular type of decision making problem where the gain a decision maker obtains as a result of his decisions is affected by the actions taken by others. Representation of alternatives' evaluations and methods to find the optimal alternative are two important aspects in the adversarial decision making. The aim of this
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

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