Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Classification of Human Decision Behavior: Finding Modular Decision Rules with Genetic Algorithms [PDF]
The understanding of human behavior in sequential decision tasks is important for economics and socio-psychological sciences. In search tasks, for example when individuals search for the best price of a product, they are confronted in sequential steps ...
Franz Rothlauf +2 more
core
Exploring the Health Literacy Behavior Patterns of Male Patients Using an Interpretable Method
Risk Management and Healthcare PolicyLizhen Huang,1,* Yanjun Jin,2,* Ching-Wen Chien,3 Qinyi Xu,3 Yen-Ching Chuang,4– 6 Tao-Hsin Tung6,7 1School of Economics and Management, Fuzhou University, Fuzhou, Fujian, 350108, People’s Republic of China; 2Department of Urology, Taizhou ...
Huang L +5 more
doaj
Personalizing ecological momentary intervention for substance use disorders through data-driven decision rules. [PDF]
Front PsychiatryKwon M +8 more
europepmc +1 more source
Evaluation of the "hemoptysis" item in clinical decision rules for the diagnosis of pulmonary embolism in the emergency department. [PDF]
Acad Emerg Med, 2022 Bannelier H +6 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
"A cross-sectional analysis of four common clinical decision rules for pulmonary embolism": The need for integrated and evolving approaches. [PDF]
J Cardiovasc Thorac ResBanisefid E, Javanshir E.
europepmc +1 more source
Inferring the decision rules that drive co-foraging affiliations in wild mixed-species parrot groups. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2023 Ferdinand V +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source