Results 151 to 160 of about 4,134,598 (285)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Aligning Noninferiority Assumptions and Decision Rules in a Protocol for a Study on Adjunctive Acupuncture for Late-Life Depression. [PDF]

JMIR Res Protoc
Shiraishi K.
europepmc   +1 more source

On Robustness of Individualized Decision Rules. [PDF]

J Am Stat Assoc, 2023
Qi Z, Pang JS, Liu Y.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Voting rules as statistical estimators [PDF]

We adopt an `epistemic' interpretation of social decisions: there is an objectively correct choice, each voter receives a `noisy signal' of the correct choice, and the social objective is to aggregate these signals to make the best possible guess about ...
Pivato, Marcus
core  

Differential Diagnosis of Parotid Tumors on Ultrasound: Interobserver Variability and Examiner-Specific Decision Rules-A Machine Learning Approach. [PDF]

Diagnostics (Basel)
Pillong L, Ohnesorg I, Brust LA, Palm J, Schulze-Berge J, Bozzato V, Voges M, Müller A, Garner M, Bozzato A.   +9 more
europepmc   +1 more source

Pruning Decision Rules by Reduct-Based Weighting and Ranking of Features. [PDF]

Entropy (Basel), 2022
Stańczyk U.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cost-Sensitive Decision Tree with Multiple Resource Constraints [PDF]

Resource constraints are commonly found in classification tasks. For example, there could be a budget limit on implementation and a deadline for finishing the classification task.
Chia-Chi WU, Kwei TANG, Yen-Liang CHEN
core  

Authors' Reply: Aligning Noninferiority Assumptions and Decision Rules in a Protocol for a Study on Adjunctive Acupuncture for Late-Life Depression. [PDF]

JMIR Res Protoc
Fu Q, Xiao K, Zhang J, Li Y, Wang Y, Jiang M, Man Z, Yang J, Lu W.   +8 more
europepmc   +1 more source