Results 141 to 150 of about 4,134,598 (285)

Clinical decision rules in primary care: necessary investments for sustainable healthcare. [PDF]

Prim Health Care Res Dev, 2023
Heerink JS, Oudega R, Hopstaken R, Koffijberg H, Kusters R.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Decision rules diverge between sympatric Featherfin cichlids despite shared preferences, ecology, and evolutionary history. [PDF]

Proc Natl Acad Sci U S A
Tomasek M, Dunster B, Goverts Z, Naceur D, Dufour V, Jordan A.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Optimizing Sequential Decision Rules for Prostate Cancer Biopsy Management: A Multi-Objective Statistical Framework. [PDF]

J Am Stat Assoc
Qiu J, Zhao YQ, Wei J, Chinnaiyan AM, Tosoian J, Zheng Y.   +5 more
europepmc   +1 more source

Use of Patient-Reported Symptom Data in Clinical Decision Rules for Predicting Influenza in a Telemedicine Setting. [PDF]

J Am Board Fam Med, 2023
Billings WZ, Cleven A, Dworaczyk J, Dale AP, Ebell M, McKay B, Handel A.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Scenario-free stochastic programming with polynomial decision rules

Multi-stage stochastic programming provides a versatile framework for optimal decision making under uncertainty, but it gives rise to hard functional optimization problems since the adaptive recourse decisions must be modeled as functions of some or all ...
Bampou, Dimitra, Kuhn, Daniel
core   +1 more source

A Narrative Review of Syncope Decision Rules: A Case for Point-of-Care Cardiac Ultrasound for Cardiac Syncope. [PDF]

J Clin Med
Situ-LaCasse E, Wallace N, Wasiak D, Patel P, Adhikari S.   +4 more
europepmc   +1 more source

Clinical decision rules in the pre-hospital triage of patients with chest pain. [PDF]

Neth Heart J, 2023
Aarts GWA, Damman P.
europepmc   +1 more source