Results 181 to 190 of about 38,631,573 (300)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Creating a Measure of Shared Decision-Making for Healthcare Decisions With Aboriginal and Torres Strait Islander People: A Hybrid Yarning and Modified Delphi Study. [PDF]

Health Expect
Tracy M, Follent D, Webster E, Dimopoulos-Bick T, Trevena LJ, Cawley M, Dickson M, Shepherd HL.   +7 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Decision-Making Balance in Coproduced Priority Setting for a Parent Carer Empowerment Intervention. [PDF]

Health Expect
Reeder J, Minhas S, Breuer E, R Smith J, Kendall S, Morris C.   +5 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Involvement of users and caregivers in mental healthcare decision-making within low-and middle-income countries: A scoping review. [PDF]

PLOS Ment Health
Amos A, Jumbe S, Bandara T, Begum S, Hanlon C, Jain S, Pickersgill M, Umar E, Stewart RC.   +8 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Communication and shared decision-making for anti-amyloid therapy in early Alzheimer's disease: An exploratory qualitative study of real-world audio-recorded clinical encounters. [PDF]

Alzheimers Dement (N Y)
Paladino J, Echols H, Thacker A, Gale SA, Ramirez Gomez L, Weizenbaum E, Pu CT, Ritchie C, Shah SJ, Lindenberger E.   +9 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Decision volume and temporal workload structure as dissociable correlates of fatigue and mood in intensive care physicians: a real-time observational study. [PDF]

Crit Care
Hieber F, Schiessl L, Herrmann A, Kohl C, Lux M, Blecha S, Lunz D, Kieninger M, Eissnert C, Kees MG, Leibold AL.   +10 more
europepmc   +1 more source