Results 181 to 190 of about 36,161,252 (288)

The Effect of Professionalism, Evidence-Based Practice and Clinical Decision-Making Levels on the Perception of Individualised Care Among Intensive Care Nurses. [PDF]

Nurs Crit Care
Kaplan E, Sir Ö, Yiğit MF, Ekremen M.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluation of a Decision Mining Tool for Nursing Quality Improvement by Hospital Nurses: Theory-Guided Qualitative Study. [PDF]

JMIR Form Res
Berkhout M, Leenen JPL, Smit K, van Houwelingen T.   +3 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Support for Disclosure of Hereditary Tumor Risk to Children and Adolescents: A Scoping Review. [PDF]

Jpn J Nurs Sci
Sugima K, Arimori N, Uchimura M, Miyauchi A, Horiuchi S.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

More than a moment: Evolving decisions among eligible volunteers in phase 1 COVID-19 vaccine trials. [PDF]

Hum Vaccin Immunother
Halperin DM, Selig BM, Condran BRJ, Davis AJ, Whittle CA, Langley JM, Halperin SA.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluation of the effect of an online patient decision aid for female stress urinary incontinence: protocol for a stepped wedge study (the Decision study)

Gerritse MB, de Vries M, Heesakkers JP, Hout JI', Lagro-Janssen AL, Vaart CHvd, Oom DM, Schellart RP, Speksnijder L, Stegeman M, Verkleij AC, Kluivers KB.   +11 more
europepmc   +1 more source

Clinicians' Perspectives on Pre-Anaesthetic Assessment and Their Attitudes Towards AI-Supported Models: Protocol for an International Survey of Anaesthesia Personnel. [PDF]

Acta Anaesthesiol Scand
Christiansen CTG, Nellemann M, Denneborg MKG, Bosholdt SA, Jakobsen JC, Hesselfeldt RT, Møller MH, Møgelmose A, Vogelius MK, Olsen MH, Buggeskov KB.   +10 more
europepmc   +1 more source