Results 191 to 200 of about 2,347,728 (267)

Acceptability, Usability, and Perceived Quality of Care of a Digital Decision Support System in Tele-Primary Health Care in Sindh, Pakistan: Sequential Explanatory Mixed Methods Pilot Study. [PDF]

JMIR Form Res
Jawed S, Tahir HN, Shaikh A, Aziz H, Khurram SS, Aga IZ, Muzzamil M, Karim M, Kazi AM, Habib SS.   +9 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Lived experiences and decision making among patients and caregivers choosing conservative kidney management: A qualitative study. [PDF]

Palliat Care Soc Pract
Loh SP, Tan AJQ, Lau WL, Chiang SY, Yeoh LY, Teh SP, Long PWY.   +6 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Patient experience data in formulary decision-making: Payer-reported perceptions and use. [PDF]

J Manag Care Spec Pharm
Kheloussi S, Mazar I, Harrington M, Perfetto EM.   +3 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparing clinical decision-making between colposcopists and large language models in cervical dysplasia management: a pilot prospective multicenter study. [PDF]

Arch Gynecol Obstet
Stalp JL, Schneider JA, Steinkasserer L, Hachenberg J, Jentschke M, Hillemanns P, Wolff D, Denecke A.   +7 more
europepmc   +1 more source