Results 141 to 150 of about 1,298,130 (287)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Artificial Intelligence-Clinical Decision Support System in Infectious Disease Control: Combatting Multidrug-Resistant Klebsiella pneumoniae with Machine Learning

open access: yesInfection and Drug Resistance
Ming-Jr Jian,1,* Tai-Han Lin,1,* Hsing-Yi Chung,1,2 Chih-Kai Chang,1 Cherng-Lih Perng,1 Feng-Yee Chang,3 Hung-Sheng Shang1 1Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center ...
Jian MJ   +6 more
doaj  

Experiences, challenges and lessons while implementing a clinical decision support system in Botswana. [PDF]

open access: yesOxf Open Digit Health
Ndlovu K   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Evaluation of a clinical decision support system for dermatology in a remote area: insights from Martinique. [PDF]

open access: yesFront Med (Lausanne)
Callens A   +16 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Correction: Five-year dementia prediction and decision support system based on real-world data. [PDF]

open access: yesFront Aging Neurosci
Exarchos TP   +14 more
europepmc   +1 more source

Usability and Perceived Usefulness of a Web‐based Clinical Decision Support System for Managing Periapical Radiolucencies in Root‐filled Teeth [PDF]

open access: hybrid
Davide J. Bottini   +5 more
openalex   +1 more source

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