Results 151 to 160 of about 1,481,839 (312)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Decision Support System (DSS) for Project Management in the Bio-diesel Industry [PDF]

The European biodiesel industry is currently facing several challenges affecting the profitability of investment projects in the industry. Among these challenges are higher prices for oilseeds, which are the main input for biodiesel production, lower ...
Alin Paul OLTEANU
core  

The PEPPER System Application Program Interface [Pòster]

, 2020
Pòster de congrés presentat a: ATTD 2020 - 13th International Conference on Advanced Technologies & Treatments for Diabetes”, celebrat a Madrid del 19 al 22 de febrer de 2020PEPPER (Patient Empowerment through Predictive PERsonalised decision support ...
Georgiou, Pantelis, Martin, Clare, Fernández-Balsells, Mercè, Avari, Parizad, López Ibáñez, Beatriz, Aldea, Arantza, Fernández-Real Lemos, José Manuel, Herrero i Viñas, Pau, Nita, Lucian, Massana i Raurich, Joaquim, Duce, David, Oliver, Nick, Leal Moncada, Yenny Teresa   +12 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Clinical Decision Support System for Post-Surgical Cardiovascular Remote Monitoring. [PDF]

Clin Pract
Pylarinou C, Mulita F, Koletsis E, Leivaditis V, Liolis E, Gortzis L, Mavrilas D.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

From Concept to Practice: Lessons From the Balanced Nursing Teams Decision-Support System. [PDF]

JMIR Nurs
Vleminckx S, Van Bogaert P, De Keyser W, Haegdorens F.   +3 more
europepmc   +1 more source

A decision support system for surgery sequencing at UZ Leuven's day-care department. [PDF]

In this paper, we test the applicability of a decision support system (DSS) that is developed to optimize the sequence of surgeries in the day-care center of the UZ Leuven Campus Gasthuisberg (Belgium).
Cardoen, Brecht, Demeulemeester, Erik
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source