Results 171 to 180 of about 1,481,839 (312)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reliability and Feasibility Assessment of EldenCare: A Geriatric Clinical Decision Support System Pilot Study. [PDF]

Hosp Pharm
Syed J, Chalasani SH, Pereira P, Sharma A, Patil V, Ramesh M, Dayananda CM, Polumuri SK, Tank NB, Pallavi TL, Deepa T, Ghule G.   +11 more
europepmc   +1 more source

DECISION SUPPORT AT THE LOGISTIC MANAGEMENT STRATEGY [PDF]

Nowadays logistics more and more often becomes the strategic issue from thepoint of view the organization aiming at reaching success in lead of its activity. The standardprocess of strategic logistics planning and management is usually periodical and the
Marta Starostka-Patyk, Iwona Grabara
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Artificial intelligence-Driven detection and decision support system for precision management of maize downy mildew. [PDF]

PLoS One
G J, Dhole A, D D.
europepmc   +1 more source

An ingenious decision support system for remote health monitoring of pregnant women

, 2012
Maternal deaths have been a critical issue for women living in rural and remote areas. The need to travel long distances, the shortage of primary care providers such as physicians, specialists and nurses, and the closing of small hospitals have been ...
Gogineni, Jyothsna
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Patients With Sepsis: Case Study. [PDF]

JMIR Med Inform
Schmiegel S, Marchi H, Hege P, Elkenkamp S, Duevel J, Düsing C, Greiner W, Scholz SS, Witzke D, Tebbe JJ, Wehmeier M, Kaup O, Borgstedt R, Rehberg S, Cimiano P, Fuchs C.   +15 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Decision-support system for live detection of Leishmania parasites from microscopic images with deep learning. [PDF]

BMC Infect Dis
Pfeil J, Amro A, Frohme M, Körber N, Lode D, Gloyer T, Gashout A, Al-Dwibe H, Nechyporenko A.   +8 more
europepmc   +1 more source