Results 111 to 120 of about 21,698,220 (290)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Early development of decision support systems based on artificial intelligence: an application to postoperative complications and a cross-specialty reporting guideline for early-stage clinical evaluation [PDF]

Background: Complications after major surgery occur in a similar manner internationally but the success of response process in preventing death varies widely depending on speed and appropriateness. Artificial intelligence (AI) offers new opportunities to
Vasey, Baptiste
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Clinician perspectives and recommendations regarding design of clinical prediction models for deteriorating patients in acute care

BMC Medical Informatics and Decision Making
Background Successful deployment of clinical prediction models for clinical deterioration relates not only to predictive performance but to integration into the decision making process. Models may demonstrate good discrimination and calibration, but fail
Robin Blythe, Sundresan Naicker, Nicole White, Raelene Donovan, Ian A. Scott, Andrew McKelliget, Steven M McPhail   +6 more
doaj   +1 more source

Clinical Decision Support Systems [PDF]

Neurosurgery, 2012
Edie E. Zusman, Yuriy Vinokur
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A novel, adaptive decision support system for diabetes self-management using artificial intelligence and mathematical modelling [Pòster]

, 2019
Pòster de congrés presentat a: ICT 2018: Imagine Digital - Connect Europe (4-6 Desembre: Viena, Austria)PEPPER (Patient Empowerment through Predictive PERsonalised decision support) is a research and innovation project to develop a personalised ...
Imperial college London, PEPPER (Patient Empowerment through Predictive PERsonalised decision support), Oxford Brookes University, Institut d’Investigació Biomèdica de Girona (IdIBGi), Universitat de Girona   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A medical informatics perspective on clinical decision support systems. Findings from the yearbook 2013 section on decision support.

, 2013
To summarize excellent research and to select best papers published in 2012 in the field of computer-based decision support in healthcare. A bibliographic search focused on clinical decision support systems (CDSSs) and computer provider order entry was ...
Section Editors For The Imia Yearbook Section On Decision, Support, Bouaud, J, Lamy, Jb   +2 more
core   +3 more sources