Results 81 to 90 of about 589,953 (289)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A survey of preparedness of teaching hospitals for developing decision support systems in Kerman University of Medical Sciences

مدیریت اطلاعات سلامت, 2015
Introduction: In this paper, first, the theoretical basis and the application of decision support systems have been reviewed. Then the readiness of teaching hospitals to developing decision support system based on a survey of senior and intermediate ...
Leila Zarei, Reza Dehnavih, Mina Anjomshoa   +2 more
doaj  

Electronic risk assessment for venous thromboembolism: investigating physicians' rationale for bypassing clinical decision support recommendations. [PDF]

, 2014
Objective: The underutilisation of venous thromboembolism (VTE) prophylaxis is still a problem in the UK despite the emergence of national guidelines and incentives to increase the number of patients undergoing VTE risk assessments.
Coleman, Jamie J., Brooks, Hannah, Coleman, Jamie J; id_orcid, Richardson, Suzanna, McFarland, Lorraine, Nwulu, Ugochi   +5 more
core   +1 more source

Clinical decision support systems for chronic obstructive pulmonary disease (COPD) in hospitals: A systematic review

, 2023
Objectives: To synthesise the literature on clinical decision support (CDS) systems for chronic obstructive pulmonary disease (COPD). We aimed to (1) describe existing COPD CDS systems that have been designed, developed or are being used in practice, (2)
Baysari, Melissa T, Mcphail, Steven M, Borg, David N, Bamgboje-Ayodele, Adeola   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An Ontological Framework for Representing Clinical Knowledge in Decision Support Systems

Journal of Telecommunications and Information Technology, 2014
In the last decades, clinical evidence and expert consensus have been encoded into advanced Decision Support Systems (DSSs) in order to promote a better integration into the clinical workflow and facilitate the automatic provision of patient specific ...
Marco Iannaccone, Massimo Esposito
doaj   +1 more source

Decision support for mastitis on farms with an automatic milking system

, 2010
For an optimal mastitis management on farms with an automatic milking system (AMS), two individual cow decisions are important. First, there is a need for decision support on which mastitis alerts have the highest priority for visual checking for ...
Dep Gezondheidszorg Landbouwhuisdieren, Advances in Veterinary Medicine, Decision Support Systems, Steeneveld, W.   +3 more
core  

Clinical decision support systems for "Making it easy to do it right"

, 2012
Medical guidelines and best practises are used in medicine to increase the quality of the health-care delivery system. To support implementation and application of these guidelines, clinical decision support systems (CDSS) have been developed.
Bergmans, J.W.M., Grouls, R.J.E., Linden, van der, C.M.J., Korsten, H., Chen, W., Bambang Oetomo, S., Ackerman, E.W., Klijn, F.A.J., Scheepers-Hoeks, A.M.J.W., Minderman, N., Feijs, L.   +10 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source