Results 91 to 100 of about 3,879,375 (275)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Data Mining – Ein neues Paradigma der angewandten Statistik

Austrian Journal of Statistics, 2016
Im Rahmen dieses Beitrages wird versucht die Unterschiede im methodologischen Ansatz bei Verfahren des Data Mining den traditionellen statistischen Modellierungskonzepten gegenüberzustellen.
Marcus Hudec
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Empirical Study of Feature Selection Methods in Regression for Large-Scale Healthcare Data: A Case Study on Estimating Dental Expenditures

IEEE Access
The complexity and high dimensionality of healthcare data present substantial challenges in building machine learning (ML) models, given the large number of variables such as patient demographics and medical history.
Veena Mayya, Christian King, Giang T. Vu, Varadraj Gurupur   +3 more
doaj   +1 more source

Some Properties of a Recently Introduced Approach to Ordinal Regression

Austrian Journal of Statistics, 2016
The statistical properties of a novel approach to ordinal regression which was only recently introduced in the literature are discussed. It is shown that for ordinal explanatory variables the approach is equivalent to isotonic regression, with some ...
Florian Frommlet
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Targeted Data Augmentation for Improving Model Robustness

International Journal of Applied Mathematics and Computer Science
This paper proposes a new and effective bias mitigation method called targeted data augmentation (TDA). Since removing biases is often tedious and challenging and may not always lead to effective bias mitigation, we propose an alternative approach ...
Mikołajczyk-Bareła Agnieszka, Ferlin Maria, Grochowski Michał   +2 more
doaj   +1 more source