Results 131 to 140 of about 648,136 (315)

Development and preliminary evaluation of a decision coach training module for nurses in Norway

BMC Nursing
Background Shared decision-making (SDM) is a collaborative patient-centred process for arriving at informed healthcare decisions. Decision coaching can help support SDM when combined with patient decision aids. As part of a meta-curriculum “Ready for SDM”
Simone Kienlin, Kari Nytrøen, Jürgen Kasper, Dawn Stacey   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

DEKAS - An evolutionary case-based reasoning system to support protection scheme design

, 2001
This paper describes a decision support system being developed in conjunction with two UK utility companies to aid the design of electrical power transmission protection systems.
Strachan, S., Gwyn, B., Farrell, J., McDonald, J. R., Duffy, A.H.B., West, G.   +5 more
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Improving shared decision-making about cancer treatment through design-based data-driven decision-support tools and redesigning care paths: an overview of the 4D PICTURE project [PDF]

Background: Patients with cancer often have to make complex decisions about treatment, with the options varying in risk profiles and effects on survival and quality of life.
Wallberg, Susanne, Schermer, Maartje H. N., Sañudo, Yeray, Dankl, Kathrina, Kuld, Anne, Nwosu, Amara C., Pross, Therese, Doornkamp, Frank, Borštnar, Simona, Sroczynski, Gaby, van Mulligen, Erik M., Lorenzo, Nora, Couespel, Norbert, Lingsma, Hester F., Svane, Inge Marie, Verheul, Elfi M., Aiger Valles, Monserrat, Pazo-Cid, Roberto, Verberne, Suzan, Antón, Antonio, Pons, Paula Gomila, Koppert, Linetta B., Siebert, Uwe, Gracia, Jorge, Romera, Juan Lao, Wee, Leonard, Rayson, Paul, Romero Piqueras, Carlos, Peric, Barbara, Donia, Marco, de Jesús, Teresa Puértolas, Roobol, Monique, Korfage, Ida J., Snelders, Dirk: on behalf of 4D Picture Consortium, Hartman, Laura, de Glas, Nienke, Karsten, Maria M., Signerez, Paula Melo, Secomandi, Fernando, Griffioen, Ingeborg, Knudsen, Bettina Mølri, Buyx, Alena, Semino, Elena, Venderbos, Lionne D. F., Kapiteijn, Ellen, Akoglu, Canan, Kremer, Marie, Kunneman, Marleen, Steyerberg, Ewout W., Silva, Marta, van Klaveren, David, Pitarch, Lucia, Hallsson, Lara R., Venegoni, Enea, Hedayati, Elham, Oliveira, Claudia Cruz, Sierra-Pérez, Jorge, Brands, Jasper B. P., Wouters, Michel, Stiggelbout, Anne M., López-Forniés, Ignacio, van Buchem, Marieke, Schreijer, Maud, Payne, Sheila A., Bangma, Chris, Rietjens, Judith A. C., Kors, Jan A., Steffensen, Karina D.   +67 more
core   +1 more source

Patient values in patient-provider communication about participation in early phase clinical cancer trials: a qualitative analysis before and after implementation of an online value clarification tool intervention

BMC Medical Informatics and Decision Making
Background Patients with advanced cancer who no longer have standard treatment options available may decide to participate in early phase clinical trials (i.e. experimental treatments with uncertain outcomes).
Liza G. G. van Lent, Mirte van der Ham, Maja J. A. de Jonge, Eelke H. Gort, Marjolein van Mil, Jeroen Hasselaar, Carin C. D. van der Rijt, Jelle van Gurp, Julia C. M. van Weert   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spreadsheet techniques for logistics decision support systems [PDF]

, 1993
This thesis considers the use of spreadsheet techniques as a foundation for the development of logistics decision support systems. An inventory model is presented to show the flexibility of spreadsheet techniques and demonstrate the use of various ...
Goeller, Dale W.
core  

Pre-triage decision support improvement in maternity care by means of data mining

, 2015
A triage system aims to make a correct characterization of the condition of patients. Because conventional triage systems like Manchester Triage System (MTS) are not suitable for maternity care, a decision model for pre-triaging patients in emergency ...
Portela, Filipe, Machado, José Manuel, António Abelha, Salazar, Maria, Santos, Manuel, Brandão, Andreia, Manuel Filipe Santos, Maria Salazar, Carlos Filipe Portela, Abelha, António, Eliana Pereira, Pereira, Eliane, José Machado, Jorge Braga, Andreia Brandão   +14 more
core   +1 more source

Patient decision aid–supported shared decision making and short-term decision-making outcomes in type 2 diabetes: a prospective observational comparative study

BMC Medical Informatics and Decision Making
Background Our study utilized patient decision aids (PDA) to explore the influence of shared decision making (SDM) on type 2 diabetes patients’ intention to use subcutaneous antidiabetic agents.
Su-Han Hsu, Cheng-Hsuan Chiang, Chia-Hui Lin, Shih-Horng Huang, Joseph Jordan Keller, Li-Hsuan Wang, Kung-Pei Tang   +6 more
doaj   +1 more source