Results 171 to 180 of about 648,136 (315)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Making agricultural support more objective-oriented: Linear programming approach for Ukraine [PDF]

In this article we investigate how to integrate the experience and knowledge of local agricultural experts in order to facilitate more objective-oriented use of the agricultural support funds.
Vysotskyi, Taras
core  

Multicriteria decision analysis in the Italian healthcare context: a review of applications and methodological approaches. [PDF]

Front Public Health
Mercati R, Vassallo C, Donnaloja F.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

IMPROVING THE QUALITY OF THE DECISION MAKING BY USING BUSINESS INTELLIGENCE SOLUTIONS [PDF]

On the basis of the decision making stands information, as one of the main elements that determine the evolution of our-days society. As a consequence, data analysis tends to become a priority in the activity of an organization for decision making.
MARIA Dan Stefan
core  

Effectiveness of memory enhancement techniques vs. conventional teaching on schizophrenia for nursing students. [PDF]

J Educ Health Promot
Sharma S, Kumari V, Kaur S, Sarin J.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A decision support system for fuzzy bilevel decision making

, 2008
Bilevel decision techniques are developed for decentralized decision problems, which may be defined by fuzzy coefficients. Based on a fuzzy linear bilevel (FLBL) model and two FLBL algorithms, this research develops a FLBL decision support system ...
Gao, Y, Zhang, G, Goyal, M, Lu, J
core  

Advances in Biosimilars: A Systematic Review of Machine Learning Applications. [PDF]

Pharmaceuticals (Basel)
Duarte V, Bas TG.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source