Results 71 to 80 of about 648,136 (315)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The impact of resources on decision making

, 2012
Decision making is a significant activity within industry and although much attention has been paid to the manner in which goals impact on how decision making is executed, there has been less focus on the impact decision making resources can have.
Boyle, Iain, Whitfield, Robert, Liu, Shaofeng, Duffy, Alexander   +3 more
core   +1 more source

QuantImage v2: a comprehensive and integrated physician-centered cloud platform for radiomics and machine learning research

European Radiology Experimental, 2023
Background Radiomics, the field of image-based computational medical biomarker research, has experienced rapid growth over the past decade due to its potential to revolutionize the development of personalized decision support models. However, despite its
Daniel Abler, Roger Schaer, Valentin Oreiller, Himanshu Verma, Julien Reichenbach, Orfeas Aidonopoulos, Florian Evéquoz, Mario Jreige, John O. Prior, Adrien Depeursinge   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Investigation of factors influencing the implementation of two shared decision-making interventions in contraceptive care: a qualitative interview study among clinical and administrative staff

Implementation Science, 2019
Background There is limited evidence on how to implement shared decision-making (SDM) interventions in routine practice. We conducted a qualitative study, embedded within a 2 × 2 factorial cluster randomized controlled trial, to assess the acceptability ...
Sarah Munro, Ruth Manski, Kyla Z. Donnelly, Daniela Agusti, Gabrielle Stevens, Michelle Banach, Maureen B. Boardman, Pearl Brady, Chrissy Colón Bradt, Tina Foster, Deborah J. Johnson, Judy Norsigian, Melissa Nothnagle, Heather L. Shepherd, Lisa Stern, Lyndal Trevena, Glyn Elwyn, Rachel Thompson   +17 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The integrated use of enterprise and system dynamics modelling techniques in support of business decisions [PDF]

, 2012
Enterprise modelling techniques support business process re-engineering by capturing existing processes and based on perceived outputs, support the design of future process models capable of meeting enterprise requirements.
Ratchev, Svetan, Agyapong-Kodua, Kwabena, Weston, R. H.   +2 more
core   +1 more source

A decision support approach for sustainability management using multiple criteria decision making and statistical techniques

Sustainable Futures
In this paper, we derive a decision support tool to establish the policies a country may carry out to direct its performance toward the Sustainable Development Goals of the 2030 Agenda.
Ana B. Ruiz, Sandra González-Gallardo, Mariano Luque, Pedro M. Fernández-Rodero, Francisco Ruiz   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source