Results 111 to 120 of about 3,836,064 (302)
Setting up a Decision Support System with Decision Tables
, 1989 :The aim of our study was to develop a decision support system using a conventional method which can be used as a shell for different applications.
V. Schwarz +3 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Applied Water ScienceDue to the pressure on South Africa’s irrigated agriculture to improve efficiency and optimal water use, irrigators must consider alternative water sources, such as root-accessible shallow groundwater tables, to supply the crop evapotranspiration ...
Ruth Hadebe +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On the conversion of decision tables to computer programs
, 1970 The use of execution time diagnostics in pinpointing ambiguities in decision tables is discussed. It is pointed out that any attempt at resolving ambiguities at compile time will, in general, be impossible.
Muthukrishnan, C. R., Rajaraman, V.
core +1 more source
Implementation of Alpha-Beta Pruning and Transposition Tables on Checkers Game
IEEE AccessCheckers is a strategy game for two players on an $8\times 8$ square board. This document outlines the creation of a checkers game, employing alpha-beta pruning as a search algorithm and transposition tables to enable the game to learn from past play ...
Cristian C. Suancha +2 more
doaj +1 more source