Results 71 to 80 of about 409,372 (266)

Incentives for Crypto-Collateralized Digital Assets

Proceedings, 2019
Digital currencies such as Bitcoin frequently suffer from high price volatility, limiting their utility as a means of purchasing power. Hence, a popular topic among cryptocurrency researchers is a digital currency design which inherits the ...
Philip N. Brown
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Probabilistic Forecast for Real-Time Control of Rainwater Pollutant Loads in Urban Environments

Hydrology
Advanced wastewater management systems are necessary to effectively direct severely contaminated initial rainwater runoff to the treatment facility only when pollutant concentrations are elevated during the initial flush event, thereby reducing the risk ...
Annalaura Gabriele, Federico Di Palma, Ezio Todini, Rudy Gargano   +3 more
doaj   +1 more source

Daniel Ellsberg and the Validation of Normative Propositions

Œconomia, 2016
In the history of decision theory Daniel Ellsberg is known because his seminal paper “Risk, ambiguity and the Savage axioms” presented the counterexample to Bayesian decision-making that got the normative value of the theory into trouble.
Carlo Zappia
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Uncertainty-Aware Multimodal Fusion and Bayesian Decision-Making for DSS

AppliedMath
Uncertainty-aware decision-making increasingly relies on multimodal sensing pipelines that must fuse correlated measurements, propagate uncertainty, and trigger reliable control actions. This study develops a unified mathematical framework for multimodal
Vesna Antoska Knights, Marija Prchkovska, Luka Krašnjak, Jasenka Gajdoš Kljusurić   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Decision-Sufficient Feature Sets, Decision Cores, and Decision Complexes: A Topological Approach to Classification

Axioms
Statistical classification is traditionally studied using probability, decision theory, information theory, and optimisation. We show that classification problems also possess a natural combinatorial and topological structure.
Sidney A. Morris
doaj   +1 more source

On the use of discrete-time quantum walks in decision theory. [PDF]

PLoS One, 2022
Chen M, Ferro GM, Sornette D.
europepmc   +1 more source