Results 51 to 60 of about 3,746,451 (299)
IEEE Access, 2022 We propose a new ML model called Topological Forest that contains an ensemble of decision trees. Unlike a vanilla Random Forest, Topological Forest has a special training process that selects a smaller number of decision trees on a topological graph ...
Murat Ali Bayir +3 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2008 Decision trees are part of the decision theory and are excellent tools in the decision-making process. Majority of decision tree learning methods were developed within the last 30 years by scholars like Quinlan, Mitchell, and Breiman, just to name a few (
John Wang, Dajin Wang
core +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
CoRR, 2020 Decision trees (DTs) epitomize what have become to be known as interpretable machine learning (ML) models. This is informally motivated by paths in DTs being often much smaller than the total number of features. This paper shows that in some settings DTs can hardly be deemed interpretable, with paths in a DT being arbitrarily larger than a PI ...
Yacine Izza +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
IEEE Transactions on Knowledge and Data Engineering, 2017 Uncovering causal relationships in data is a major objective of data analytics. Causal relationships are normally discovered with designed experiments, e.g. randomised controlled trials, which, however are expensive or infeasible to be conducted in many cases.
Jiuyong Li +4 more
openaire +3 more sources
, 2020 Decision trees with improved ...
Juan Antonio Caballero-Hernández (6681491)
core +1 more source