Results 51 to 60 of about 169,825 (305)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2015 Model tree induction is a popular method for tackling regression problems requiring interpretable models. Model trees are decision trees with multiple linear regression models at the leaf nodes.
Kramer, Stefan +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A mass assignment based ID3 algorithm for decision tree induction
, 1997 A mass assignment based ID3 algorithm for learning probabilistic fuzzy decision trees is introduced. Fuzzy partitions are used to discretize continuous feature universes and to reduce complexity when universes are discrete but with large cardinalities ...
Baldwin, JF, Martin, TP, Lawry, J
core +1 more source
Bivariate decision trees [PDF]
, 1997 Decision tree methods constitute an important and much used technique for classification problems. When such trees are used in a Datamining and Knowledge Discovery context, ease of interpretation of the resulting trees is an important requirement to be met.
Bioch, JC (Cor) +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Integration of Decision Trees Using Distance to Centroid and to Decision Boundary [PDF]
Journal of Universal Computer Science, 2020 Plethora of ensemble techniques have been implemented and studied in order to achieve better classification results than base classifiers. In this paper an algorithm for integration of decision trees is proposed, which means that homogeneous base ...
Jedrzej Biedrzycki, Robert Burduk
doaj +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
CoRR, 2013 This paper describes experiments, on two domains, to investigate the effect of averaging over predictions of multiple decision trees, instead of using a single tree. Other authors have pointed out theoretical and commonsense reasons for preferring the multiple tree approach.
Suk Wah Kwok, Chris Carter
openaire +2 more sources