Results 51 to 60 of about 137,982 (257)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
IEEE AccessThis paper investigates classes of decision tables (DTs) with 0-1-decisions that are closed under the removal of attributes (columns) and changes to the assigned decisions to rows.
Azimkhon Ostonov, Mikhail Moshkov
doaj +1 more source
Method of decision tree applied in adopting the decision for promoting a company
Annals of Spiru Haret University Economic Series, 2015 The decision can be defined as the way chosen from several possible to achieve an objective. An important role in the functioning of the decisional-informational system is held by the decision-making methods.
Cezarina Adina TOFAN
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A Modified Random Forest Based on Kappa Measure and Binary Artificial Bee Colony Algorithm
IEEE Access, 2021 Random forest (RF) is an ensemble classifier method, all decision trees participate in voting, some low-quality decision trees will reduce the accuracy of random forest.
Chen Zhang +5 more
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IEEE Transactions on Knowledge and Data Engineering, 2017 Uncovering causal relationships in data is a major objective of data analytics. Causal relationships are normally discovered with designed experiments, e.g. randomised controlled trials, which, however are expensive or infeasible to be conducted in many cases.
Jiuyong Li +4 more
openaire +2 more sources
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Machine Learning Methods with Decision Forests for Parkinson’s Detection
Applied Sciences, 2021 Biomedical engineers prefer decision forests over traditional decision trees to design state-of-the-art Parkinson’s Detection Systems (PDS) on massive acoustic signal data.
Moumita Pramanik +4 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
MAPTree: Beating “Optimal” Decision Trees with Bayesian Decision Trees
Proceedings of the AAAI Conference on Artificial IntelligenceDecision trees remain one of the most popular machine learning models today, largely due to their out-of-the-box performance and interpretability. In this work, we present a Bayesian approach to decision tree induction via maximum a posteriori inference of a posterior distribution over trees.
Colin Sullivan +2 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source