Results 71 to 80 of about 4,714,659 (255)

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Stakeholders influence on managers' environmental behaviors [PDF]

, 2009
La importancia del medioambiente ha aumentado tanto en teoría como en práctica en los últimos años. Los “stakeholders” – empleados, proveedores, accionistas, gobiernos, organizaciones no gubernamentales – han jugado un papel fundamental en la ...
Cossío Silva, Francisco José (Coordinador), Delgado Ceballos, Javier, Rueda Manzanares, Antonio   +2 more
core  

Efectos de la impulsividad y el consumo de alcohol sobre la toma de decisiones en los adolescentes

, 2015
Fundamentacion: la adolescencia es un periodo asociado al inicio y la progresion del consumo de alcohol. En esta etapa tambien son frecuentes las conductas impulsivas y la toma de decisiones (TD) riesgosas.
M. Caña, Y. Michelini, Ignacio Acuña, J. Godoy   +3 more
semanticscholar   +1 more source

Engineering hierarchical complex systems: an agent-based approach. The case of flexible manufacturing systems [PDF]

Studies in Computational Intelligence, Volume 402, p. 49-60 2012, 2012
This article introduces a formal model to specify, model and validate hierarchical complex systems described at different levels of analysis. It relies on concepts that have been developed in the multi-agent-based simulation (MABS) literature: level, influence and reaction.
arxiv   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Toma de decisiones: reto para crear ventajas competitivas en las distribuidoras de alimentos gourmet

, 2015
El proceso de toma de decisiones constituye el motor que materializa el exito de los negocios. Por esta razon, el presente articulo de investigacion tuvo como proposito analizar la toma de decisiones y su incidencia para crear ventajas competitivas en ...
Paz Annherys, Harris Jaiham, Jesús García   +2 more
semanticscholar   +1 more source

PROSPECTIVE AND SCORECARD, A STRATEGIC WEAPON AGAINST ENVIRONMENTAL CHANGES

Anuario Facultad de Ciencias Económicas y Empresariales, 2016
Until the decade of the 70 the nucleus of the concern in companie´s bussiness management was constituted it the achievement of the efficiency, a very important economic condition, but with the turbulence of the environment this condition was necessary ...
María del C. Herrero-Infante, Yanet Mora-Herrero   +1 more
doaj  

Reconstruction of Epsilon-Machines in Predictive Frameworks and Decisional States [PDF]

arXiv, 2009
This article introduces both a new algorithm for reconstructing epsilon-machines from data, as well as the decisional states. These are defined as the internal states of a system that lead to the same decision, based on a user-provided utility or pay-off function.
arxiv  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Instrumentos económicos para la gestión ambiental : decisiones monocriteriales versus decisiones multicriteriales [PDF]

, 2004
El análisis de temas complejos como la sostenibilidad, de naturaleza multidimensional, requiere instrumentos analíticos que capten las distintas dimensiones del problema, incluyendo las cosmovisiones e intereses de los actores involucrados, no siempre ...
Burbano, Rafael, Falconí Benítez, Fander   +1 more
core   +1 more source