Results 161 to 170 of about 2,176,289 (311)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Using full agreement across multiple large language models for title-and-abstract screening in systematic reviews: a proof-of-concept. [PDF]

Syst Rev
Hilkenmeier F, Stoltenberg M, Stierle C.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

OFF-FARM EMPLOYMENT DECISIONS BY MASSACHUSETTS FARM HOUSEHOLDS

The off-farm labor participation and supply decisions of Massachusetts farm families were estimated in a model which allows for joint decisions. The hypothesis of joint off-farm participation decisions by operators and spouses was rejected.
Hallberg, Milton C., Lass, Daniel A., Findeis, Jill L.   +2 more
core  

The Effect of Expected Income on Individual Migration Decisions [PDF]

The paper develops a tractable econometric model of optimal migration, focusing on expected income as the main economic influence on migration. The model improves on previous work in two respects: it covers optimal sequences of location decisions (rather
James R. Walker, John Kennan
core  

Real-World Evidence for Drug Value Assessment in China: Learning from International Experiences. [PDF]

Drugs Real World Outcomes
Hartzema AG, Gehchan A, Guo JD, Xuan J.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

What is herd health management? A narrative review. [PDF]

Acta Vet Scand
Eriksen EØ, Pedersen KS, Nielsen JP.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Advanced cancer treatment decisions and their patient-facing financial burdens: a thematic analysis. [PDF]

Oncologist
Forcino RC, Mathur D, Perry AN, Wasp GT, Barnato AE.   +4 more
europepmc   +1 more source