Results 71 to 80 of about 2,380,234 (309)

A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

CPT: Pharmacometrics & Systems Pharmacology
Assessment of drug‐induced effects on the cardiovascular (CV) system remains a critical component of the drug discovery process enabling refinement of the therapeutic index. Predicting potential drug‐related unintended CV effects in the preclinical stage
Victoria Kulesh, Igor Vasyutin, Alina Volkova, Kirill Peskov, Holly Kimko, Victor Sokolov, Ravindra Alluri   +6 more
doaj   +1 more source

Increase anti‐poaching law‐enforcement or reduce demand for wildlife products? A framework to guide strategic conservation investments

Conservation Letters, 2019
Donors, NGOs, and governments increasingly invest in campaigns to reduce consumer demand for wildlife products in an attempt to prevent the decline of overexploited and poached species. We provide a novel framework to aid these investment decisions based
Matthew H. Holden, Duan Biggs, Henry Brink, Payal Bal, Jonathan Rhodes, Eve McDonald‐Madden   +5 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Synchronized Multi-Point UAV-Based Traffic Monitoring for Urban Infrastructure Decision Support

Drones
This study presents a comprehensive methodology for urban traffic monitoring and infrastructure decision making, centered on synchronous, simultaneous aerial data collection through a distributed multi-point UAV deployment.
Igor Kabashkin, Alua Kulmurzina, Batyrlan Nadimov, Gulnar Tlepiyeva, Zura Sansyzbayeva, Timur Sultanov   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Letter to Jane Howe Gregory from Republicans for Responsible Decisions

, 1991
This letter from Republicans for Responsible Decisions includes an outline of the goals and platform of the organization and a partial list of the organization's leadership and ...
Republicans for Responsible Decisions
core  

Remediation of 1,2 DCA in Fractured Bedrock Using EHC® ISCR

Revista Águas Subterrâneas, 2013
Objectives Remediation of 1,2 DCA in fractured bedrock was conducted using the EHC® amendment. EHC amendment treats 1,2DCA via in situ chemical reduction (ISCR) and by creating reducing conditions in the aquifer.
JIM MUELLER, FAYZ LAKHWALA, ED VANYO, JOHN M.(JAY) ASH   +3 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Risk expression using likelihood ratios and natural frequencies in Bayesian inference tasks—a preregistered randomized-controlled crossover trial

BMC Medical Education
Background To make reasonable future medical decisions, medical students need to be sufficiently educated to interpret diagnostic tests. Natural frequencies are considered the gold standard for understanding single diagnostic test results.
Philipp Schulz, Odette Wegwarth, Helge Giese   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source