Results 71 to 80 of about 30,536 (239)

RETRACTED ARTICLE: The predictive value of BTG1 for the response of newly diagnosed acute myeloid leukemia to decitabine

Clinical Epigenetics
Background Decitabine has been widely used to treat acute myeloid leukemia (AML); however as AML is a heterogeneous disease, not all patients benefit from decitabine. This study aimed to identify markers for predicting the response to decitabine. Methods
Yi Li, Xia Mao, Mengyuan Li, Li Li, Xiwen Tong, Lifang Huang   +5 more
doaj   +1 more source

Total DNA methylation in the brain in response to decitabine treatment in female rats

European Pharmaceutical Journal, 2019
Hypomethylating agent decitabine is being used in the treatment of certain types of leukaemia in combination with other anticancer drugs. Aberrant DNA methylation has been suggested to occur in pathological states including depression.
Balagova L., Buzgoova K., Karailiev P., Jezova D.   +3 more
doaj   +1 more source

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell–mediated toxicity against glioblastoma

Neuro-Oncology, 2022
Background Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite maximal treatment, median survival remains dismal at 14–24 months.
Ruichong Ma, Margarida Rei, Isaac B. Woodhouse, Katherine Ferris, Sophie A. Kirschner, Anandhakumar Chandran, U. Gileadi, Ji-Li Chen, Mariana Pereira Pinho, Y. Ariosa-Morejon, S. Kriaučionis, N. Ternette, H. Koohy, O. Ansorge, G. Ogg, P. Plaha, V. Cerundolo   +16 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiveness

Advances in Hematology, 2015
Introduction. The incidence of Acute Myeloid Leukemia (AML) increases progressively with age and its treatment is challenging. This prospective case control study was undertaken to compare the safety, efficacy, and cost-effectiveness of decitabine with ...
Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu   +6 more
doaj   +1 more source

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia

Blood, 2021
New treatment options are required for patients with refractory immune thrombocytopenia (ITP), a disease in which immune tolerance has been lost due to reduced regulatory T-cell (Treg) activity.
P. Han, Yu Hou, Yajing Zhao, Yang Liu, Tian-shu Yu, Yunqi Sun, Haoyi Wang, Pengcheng Xu, Guo-sheng Li, Tao Sun, Xiang Hu, Xinguang Liu, Li-zhen Li, J. Peng, Hai Zhou, M. Hou   +15 more
semanticscholar   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway

Frontiers in Immunology, 2020
Organ dysfunction caused by sepsis is life-threatening and results in high mortality. Therapeutic options for sepsis are limited. Pathogenic factors are considered as components of environmental pressure that modify DNA methylation patterns thereby ...
Luxi Cao, Luxi Cao, Luxi Cao, Luxi Cao, Luxi Cao, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Ping Zhang, Ping Zhang, Ping Zhang, Ping Zhang, Ping Zhang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +59 more
doaj   +1 more source