Results 41 to 50 of about 44,092 (218)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Algorithmization and Hardware Implementation of Polar Coding for 5G Telecommunications

Transport and Telecommunication
The article explores a recursive algorithm for determining Bhattacharyya parameters, which is a measure of the degree of channel polarization for telecommunications with polar coding.
Pyatin Ilya, Boiko Juliy, Eromenko Oleksander   +2 more
doaj   +1 more source

SPADE: Superpixel Adjacency Driven Embedding for Three-Class Melanoma Segmentation

Algorithms
The accurate segmentation of pigmented skin lesions is a critical prerequisite for reliable melanoma detection, yet approximately 30% of lesions exhibit fuzzy or poorly defined borders.
Pablo Ordóñez, Ying Xie, Xinyue Zhang, Chloe Yixin Xie, Santiago Acosta, Issac Guitierrez   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A low power and high speed decoder design based on FPGA

Dianzi Jishu Yingyong, 2018
In view of the complexity and inflexibility of the traditional encoding and decoding algorithms, this paper studies the forward propagation algorithm and structure of autoencoder neural networks.
Zhou Songjiang, Li Shengchen, Liu Ming
doaj   +1 more source

Clinical tooth segmentation based on local enhancement

Frontiers in Molecular Biosciences, 2022
The tooth arrangements of human beings are challenging to accurately observe when relying on dentists’ naked eyes, especially for dental caries in children, which is difficult to detect. Cone-beam computer tomography (CBCT) is used as an auxiliary method
Jipeng Wu, Ming Zhang, Delong Yang, Delong Yang, Feng Wei, Naian Xiao, Lei Shi, Huifeng Liu, Peng Shang   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Voxel Generator Based on Autoencoder

Applied Sciences, 2022
In recent years, 3D models have been widely used in the virtual/augmented reality industry. The traditional way of constructing 3D models for real-world objects remains expensive and time-consuming. With the rapid development of graphics processors, many
Bo-Cheng Huang, Yu-Cheng Feng, Tyng-Yeu Liang   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Development and Progress of the UWB Physical Layer

Micromachines, 2022
Ultra-wideband (UWB) technology has been applied in many fields, such as radar and indoor positioning, because of its advantages of having a high transmission rate, anti-multipath interference, and good concealment.
Ziteng Lv, Xin Zhang, Dongdong Chen, Di Li, Xianglong Wang, Tianlong Zhao, Yintang Yang, Yanbo Zhao, Xin Zhang   +8 more
doaj   +1 more source