Results 61 to 70 of about 102,145 (296)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Multitask-Based Neural Machine Translation Model with Part-of-Speech Tags Integration for Arabic Dialects

Applied Sciences, 2018
The statistical machine translation for the Arabic language integrates external linguistic resources such as part-of-speech tags. The current research presents a Bidirectional Long Short-Term Memory (Bi-LSTM)—Conditional Random Fields (CRF) segment-
Laith H. Baniata, Seyoung Park, Seong-Bae Park   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Design of Parallel Multiplier Based on Radix-4 Booth Coding [PDF]

Zhengzhou Daxue xuebao. Gongxue ban
Speed and area are two basic indexes to evaluate the performance of multiplier unit. Aiming at the problem of balancing layout area and transmission delay in current multiplier design, a new 16-bit signed fixed-point multiplier was designed by using ...
FAN Wenbing, ZHOU Jianzhang
doaj   +1 more source

Least squares decoding in binomial frequency division multiplexing

ETRI Journal, 2023
This paper proposes a method that can reduce the complexity of a system matrix by analyzing the characteristics of a pseudoinverse matrix to receive a binomial frequency division multiplexing (BFDM) signal and decode it using the least squares (LS ...
Myungsup Kim, Jiwon Jung, Ki-Man Kim
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

SN-FPN: Self-Attention Nested Feature Pyramid Network for Digital Pathology Image Segmentation

IEEE Access
Digital pathology has played a key role in replacing glass slides with digital images, enhancing various pathology workflows. Whole slide images are digitized pathological images improving the capabilities of digital pathology and contributing to the ...
Sanghoon Lee, Kazi Aminul Islam, Sai Chandana Koganti, Varshini Yaganti, Sai Ramya Sri Mamillapalli, Hannah Vitalos, Drew F. K. Williamson   +6 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source