Results 41 to 50 of about 4,421 (165)

New defining body (Ugras body) in polypoid dedifferentiated liposarcoma of the vallecula. Histomorphological, immunohistochemical and molecular genetic findings

Indian Journal of Pathology and Microbiology, 2020
This is a description of a dedifferentiated liposarcoma seen in a 27-year-old female patient. The tumor originated from the vallecula and contains distinctive bodies.
Serdar Ugras, Markku Miettinen
doaj   +1 more source

A subset of high‐grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung, Carla Saoud, Sarah Chiang, Meera Hameed, Cristina R Antonescu   +4 more
wiley   +1 more source

Combination Therapy With Sintilimab and Anlotinib for Advanced Undifferentiated Pleomorphic Sarcoma: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT This report describes the case of a 73‐year‐old woman with advanced undifferentiated pleomorphic sarcoma (UPS) who was intolerant to chemotherapy. Following amputation, she received sintilimab plus anlotinib and achieved a partial response with 76.6% tumor reduction.
Yan Chen, Ronghua Chu
wiley   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Dedifferentiated Liposarcoma of the Gastroesophageal Junction [PDF]

Türk Patoloji Dergisi, 2018
Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration ...
Gökçe AŞKAN, Pelin BAĞCI, Meera HAMEED, Olca BAŞTÜRK   +3 more
doaj  

Concomitant Medication Effects on Immunotherapy Outcomes in Sarcoma: A Pooled Post Hoc Analysis of Seven Phase II Trials

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Concomitant medications (CMs) influence outcomes in patients receiving immune checkpoint inhibitors (ICIs), but their impact in sarcoma remains undefined. We assessed the association between CM use and ICI outcomes in patients with advanced or metastatic sarcoma. Methods This pooled analysis included patients from seven investigator‐
Adel Shahnam, Kristen DiConza, Simran Jasnani, Rhoena Desir‐Camille, Evan Rosenbaum, Olayode Babatunde, Ciara M. Kelly, Lauren B. Banks, Viswatej Avutu, Ping Chi, Sujana Movva, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Robert G. Maki, William D. Tap, Sandra P. D'Angelo   +16 more
wiley   +1 more source

Evaluating Variability in Extracellular Vesicle Characterization Across Measurement Techniques

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Reliable, reproducible, and standardized characterization of extracellular vesicles (EVs) remains a central challenge due to methodological variability across analytical platforms and intrinsic EV heterogeneity within and across biofluids. Here, we evaluated EVs isolated using ultracentrifugation from dedifferentiated liposarcoma‐conditioned ...
Premanshu K. Singh, Ali F. Usmani, Debmalya Halder, Jenna Miller, Tharune Kanagasabai, Patricia Sarchet, Kevin Weller, George J. Klarmann, Raphael E. Pollock, Federica Calore, Shaurya Prakash   +10 more
wiley   +1 more source

A case of primary orbital liposarcoma with dedifferentiated transformation from a well-differentiated form

American Journal of Ophthalmology Case Reports
Purpose: Primary orbital liposarcomas are rare. To the best of our knowledge, only four cases of primary dedifferentiated liposarcomas of the orbit have been reported.
Mika Tanabe, Hiroshi Yoshikawa, Masatoshi Fukushima, Masahiro Mizoguchi, Masato Akiyama, Yuhei Sangatsuda, Fumiya Narutomi, Koh-Hei Sonoda   +7 more
doaj   +1 more source

Dedifferentiated liposarcoma with heterologous spindle cell rhabdomyoblastic de-differentiation: An unusual pattern expanding the morphological spectrum

Indian Journal of Pathology and Microbiology, 2020
Dedifferentiated liposarcoma (DDLS) is characterized by a wide histopathological spectrum. Spindle cell type of rhabdomyoblastic dedifferentiation has been rarely described in case of DDLS.
Bharat Rekhi, Akshay D Baheti, Shraddha Patkar   +2 more
doaj   +1 more source

Pleomorphic Leiomyosarcoma of the Jejunoileal Mesentery: A Histopathological Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Gastrointestinal leiomyosarcomas are rare malignancies. Herein, we present a case report of a previously healthy 60‐year‐old female presenting with periumbilical abdominal pain, vomiting, and difficulty in passing stool, with clinical workup, imaging, and surgery defining a small intestine tumor.
George S. Stoyanov, Zlatko Zlatev, Andrea Kirilova, Kristina Naydenova, Hristo Popov   +4 more
wiley   +1 more source