Results 41 to 50 of about 2,061,737 (311)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Influence of alternating bending on springback behavior of parts in deep drawing process with macro-structured tools

MATEC Web of Conferences, 2018
In today’s industry, waste prevention and an efficient use of resources are becoming more important due to economic and environmental requirements. Especially in forming processes such as deep drawing, a reduced use of lubricants is highly promising for ...
Mousavi Ali, Ridolfi Kevin Sven, Brosius Alexander   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

eulerAPE: Drawing Area-proportional 3-Venn Diagrams Using Ellipses [PDF]

, 2014
Venn diagrams with three curves are used extensively in various medical and scientific disciplines to visualize relationships between data sets and facilitate data analysis.
Luana Micallef, Rodgers, Peter, Rodgers Peter, Micallef Luana, Peter Rodgers, Micallef, Luana   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Study of Deep Drawing Combined with Ironing of A7075 Aluminum Alloy [PDF]

MATEC Web of Conferences
This study focuses on the process analysis and pass design of compound deep drawing with ironing processes of A7075 aluminum alloy. At first, A7075-T6 aluminum alloy workpiece is annealed to enhance the formability.
Hwang Yeong-Maw, Wu Yen-Lin, Wang Cheng-Chi   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Comparative Simulation Study on Springback and Formability Square Cups: Hydromechanical vs. Conditional Deep Drawing

Journal of Machine Engineering
This paper presents a comparative simulation study on springback and formability in square cup manufacturing using Conventional (CDD) and Hydromechanical Deep Drawing (HMDD).
Quang Vu Duc
doaj   +1 more source

Study on micro extra deep drawing process with ultrahigh fluid pressure and press motion controls

MATEC Web of Conferences, 2015
A novel micro extra deep drawing process with ultrahigh fluid pressure and press motion controls are developed. A space between the blank and 1st punch is made by the press motion at the 2nd drawing stage and the ultrahigh pressure is applied so as to be
Sato Hideki, Kondo Daiki, Manabe Ken-ichi, Ito Kuniyoshi   +3 more
doaj   +1 more source