Results 51 to 60 of about 2,061,737 (311)

A graph rewriting programming language for graph drawing [PDF]

open access: yes, 1998
This paper describes Grrr, a prototype visual graph drawing tool. Previously there were no visual languages for programming graph drawing algorithms despite the inherently visual nature of the process.
Rodgers, Peter
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

DETERMINATION OF THE SIZE OF BLANK NECESSARY TO OBTAIN A DEEP DRAWING USING SOLIDWORKS [PDF]

open access: yesFiabilitate şi Durabilitate, 2011
The development of the approximate blank size should be done to determine the size of a blank to produce the shell to the required depth and to determine how many draws will be necessary to produce the shell.
Alin STĂNCIOIU   +2 more
doaj  

Crystal plasticity finite element method application in micro/meso-scaled deep drawing and some related concerns [PDF]

open access: yes
The crystal plasticity finite element method (CPFEM) has been widely used in the research of micro/meso-scaled deformation of materials. In this talk, the effectiveness of CPFEM in simulating deep drawing processes is highlighted, with a particular focus
Xu Tong   +5 more
core   +1 more source

A numerical study on warm deep drawing of polypropylene

open access: yes, 2023
Warm deep drawing of polypropylene, a semi-crystalline thermoplastic polymer, is studied using finite element analysis. In this process, a circular polypropylene blank is preheated to a temperature much below its melting temperature and deep drawn into ...
Emani, Chandra Kishore Reddy   +3 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

ANALISIS SQUARE CUP DEEP DRAWING

open access: yesMedia Mesin, 2007
The applications of sheet metal forming is very important in the automotive industries since most of the car components are produced by press forming processes.
Uud Achmad Imadudin, Marwan Effendy
doaj  

Drawing Graphs in Euler Diagrams [PDF]

open access: yes, 2004
We describe a method for drawing graph-enhanced Euler diagrams using a three stage method. The first stage is to lay out the underlying Euler diagram using a multicriteria optimizing system. The second stage is to find suitable locations for nodes in the
Rodgers, Peter   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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