Results 91 to 100 of about 241,500 (289)

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo   +5 more
wiley   +1 more source

Vortex-Induced Vibration of Deep-Sea Mining Pipes: Analysis Using the Slicing Method

open access: yesApplied Sciences
Deep-sea mining pipes are different from traditional ocean risers articulated at both ends: they are free-suspended, weakly constrained at the bottom, and have an intermediate silo at the end, compared to which relatively little research has been carried
Xiangzhao Wu   +4 more
doaj   +1 more source

Biotechnological aspects of sulfate reduction with methane as electron donor [PDF]

open access: yes, 2010
Biological sulfate reduction can be used for the removal and recovery of oxidized sulfur compounds and metals from waste streams. However, the costs of conventional electron donors, like hydrogen and ethanol, limit the application possibilities.
Lens, P.N.L.   +2 more
core   +2 more sources

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

open access: yesAdvanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang   +14 more
wiley   +1 more source

Numerical simulations and large-scale experimental research into air-lifting system for deep-sea mining

open access: yesInternational Journal of Naval Architecture and Ocean Engineering
The deep seabed harbors abundant mineral resources. To achieve the economic viability of deep-sea mining, the efficiency of polymetallic nodule lifting is critical.
JianYu Xiao   +4 more
doaj   +1 more source

Feasibility study on manganese nodules recovery in the Clarion-Clipperton Zone

open access: yes, 2012
The sea occupies three quarters of the area on the earth and provides various kinds of resources to mankind in the form of minerals, food, medicines and even energy.
Agarwal, Baivau   +4 more
core  

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

open access: yesAdvanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin   +19 more
wiley   +1 more source

Experimental Study on the Shear Characteristics of Deep-Sea Sediments Based on a Mining Machine Walking Test Platform

open access: yesAdvances in Civil Engineering
The exploitation and utilization of deep-sea mineral resources is an important measure to ensure the safety of resources. The shear characteristics of deep-sea sediments are fundamental parameters for the design of a machine for mining polymetallic ...
Xiaoyan Li   +4 more
doaj   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du   +18 more
wiley   +1 more source

Real-Time Prediction of the Dynamic Spatial Configuration of Umbilical Cables Based on Monitoring Data During Deep-Sea In-Situ Mining

open access: yesJournal of Marine Science and Engineering
Prediction of the spatial configuration of the umbilical cable during deep-sea mining in-situ tests is of great significance because dynamic change may cause the umbilical cable to touch the ground or overturn the mining vehicle.
Chaojun Huang   +10 more
doaj   +1 more source

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