Results 101 to 110 of about 242,470 (302)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Experimental Study on the Shear Characteristics of Deep-Sea Sediments Based on a Mining Machine Walking Test Platform

Advances in Civil Engineering
The exploitation and utilization of deep-sea mineral resources is an important measure to ensure the safety of resources. The shear characteristics of deep-sea sediments are fundamental parameters for the design of a machine for mining polymetallic ...
Xiaoyan Li, Lang Lei, Shengwei Zhao, Jenisha Singh, Zhou Li   +4 more
doaj   +1 more source

Numerical simulations and large-scale experimental research into air-lifting system for deep-sea mining

International Journal of Naval Architecture and Ocean Engineering
The deep seabed harbors abundant mineral resources. To achieve the economic viability of deep-sea mining, the efficiency of polymetallic nodule lifting is critical.
JianYu Xiao, Zhuang Kang, Jing Leng, Ming Chen, Jun Liu   +4 more
doaj   +1 more source

Advisory opinion on responsibility and liability for international seabed mining (ITLOS Case No. 17): international environmental law in the seabed disputes chamber [PDF]

, 2011
On 1 February 2011, the Seabed Disputes Chamber (“the Chamber”) delivered its first Advisory Opinion. The Opinion provides useful guidance to the international community concerned with the deep seabed.
Anton, Donald, Makgill, Robert, Payne, Cymie   +2 more
core   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

Real-Time Prediction of the Dynamic Spatial Configuration of Umbilical Cables Based on Monitoring Data During Deep-Sea In-Situ Mining

Journal of Marine Science and Engineering
Prediction of the spatial configuration of the umbilical cable during deep-sea mining in-situ tests is of great significance because dynamic change may cause the umbilical cable to touch the ground or overturn the mining vehicle.
Chaojun Huang, Shuqing Wang, Jiancheng Liu, Lei Li, Wencheng Liu, Lin Huang, Zhihao Yu, Wen Shen, Yuankun Sun, Yu Liu, Yuanyuan Liu   +10 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

New Geothermal Prospect in North-Eastern Morocco [PDF]

, 2010
Geothermal data has been indicating promising potentialities in the north-eastern Morocco. This paperpresents new temperature data, recently recorded in water borehole located in the Berkane and Oujda areas.
Barkaoui, Alae Eddine, Boughriba, Mimoun, Carneiro, Júlio, Correia, António, Lucazeau, Francis, Rimi, Abdelkrim, Verdoya, Massimo, Zarhloule, Yassine   +7 more
core  

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source