Results 121 to 130 of about 4,786,586 (289)

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Research status and analysis of deep-sea metal mining equipment and technologies

Meitan xuebao
Metal mineral resources are critical materials for the world economic development. In a situation of weak supply of terrestrial rare metals, many countries are expanding the direction of resource extraction from a land-based approach to a land-sea ...
Yongping JIN, Xiangyang DONG, Buyan WAN, Deshun LIU   +3 more
doaj   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Research on the Unsteady Flow Characteristics of Solid–Liquid Two-Phase Flow in a Deep-Sea Mining Lift Pump and Model Experimental Verification

Journal of Marine Science and Engineering
The deep-sea mining lift pump is one of the pivotal components in deep-sea mineral transportation systems and its internal flow is very complex; consequently, unraveling its unsteady flow behavior pattern holds immense practical value.
Shunjun Hong, Junhong Hu, Pengyun Wei, Haizhong Man, Zihai Yang, Jing Wu, Xiaozhou Hu   +6 more
doaj   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Sediment plumes resulting from deep sea mining

, 2013
At present there is a keen interest in the recovery of valuable raw materials— polymetallic and phosphorous nodules, sulphurous deposits and metallic muds – from deep sea environments.
Spearman, J., Matthewson, T.
core   +1 more source

Stress Evaluation of a Maritime A-Frame Using Limited Strain Measurements from a Real Deep-Sea Mining Campaign

Journal of Marine Science and Engineering
As terrestrial resources become increasingly scarce, the exploration and utilization of marine resources have become crucial for ensuring a stable resource supply.
Jiahui Ji, Chunke Ma, Ying Li, Mingqiang Xu, Wei Liu, Hong Zhen, Jiancheng Liu, Shuqing Wang, Lei Li, Lianjin Jiang   +9 more
doaj   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Research on Predicting the Mechanical Characteristics of Deep-Sea Mining Transportation Pipelines

Applied Sciences
Deep-sea mining, as a critical direction for the future development of mineral resources, places significant importance on the mechanical characteristics of its transportation pipelines for the safety and efficiency of the entire mining system.
Qiong Hu, Yu Qin, Jingyan Zhu, Meiling Zheng, Junqiang Huang, Yujia Ou   +5 more
doaj   +1 more source

Introduction to deep sea mining activities in the Pacific region.

, 2018
Introduction to Marine Policy Special Issue on Deep Sea Mining Activities in the Pacific Region.
Smith, Hance
core   +1 more source