Results 31 to 40 of about 174,348 (267)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Deformation Rules for Surrounding Rock in Directional Weakening of End Roofs of Thin Bedrocks and Ultrathick Seams

Advances in Civil Engineering, 2020
With the deployment of China’s energy strategy in the western regions, complex geological mining conditions such as thin bedrock and ultrathick seams in western China have caused a series of problems such as serious deformation of the surrounding rock at
Fei Liu, Zhanguo Ma, Yongsheng Han, Zhimin Huang   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analytical Study of Soil Displacement Induced by Twin Shield Tunneling in Semi-Infinite Viscoelastic Ground

Advances in Civil Engineering, 2020
Effective measures are needed to strictly control soil displacement caused during the process of shield construction excavation for urban subway tunnels.
Xin Shi, Chuanxin Rong, Houliang Wang, Linzhao Cui, Haibing Cai, Bin Wang   +5 more
doaj   +1 more source

Oil and gas resource potential in the deep-water Canada Basin, Arctic Ocean

, 2018
The Canada Basin is a deep-water basin adjacent to the Arctic continental shelves of northwest Canada and northern Alaska. Perennial ice cover in the Arctic Ocean has historically prevented detailed geologic study of the basin. Recent seismic surveys (2007 to 2011) provide substantial new information on crustal architecture and sediment fill of the ...
P K Hannigan, J R Dietrich, Z Chen, K Hu, X Yu   +4 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A rotational ellipsoid model for solid Earth tide with high precision

Scientific Reports
Solid Earth tide represents the response of solid Earth to the lunar (solar) gravitational force. The yielding solid Earth due to the force has been thought to be a prolate ellipsoid since the time of Lord Kelvin, yet the ellipsoid’s geometry such as ...
Yongfeng Yang, Yunfei Zhang, Qiang Liu, Xianqing Lv, Pu Huang   +4 more
doaj   +1 more source

Proteomic Characterization of Proliferation Inhibition of Well-Differentiated Laryngeal Squamous Cell Carcinoma Cells Under Below-Background Radiation in a Deep Underground Environment

Frontiers in Public Health, 2020
Background: There has been a considerable concern about cancer induction in response to radiation exposure. However, only a limited number of studies have focused on the biological effects of below-background radiation (BBR) in deep underground ...
Jifeng Liu, Jifeng Liu, Tengfei Ma, Tengfei Ma, Mingzhong Gao, Yilin Liu, Jun Liu, Shichao Wang, Yike Xie, Qiao Wen, Ling Wang, Juan Cheng, Shixi Liu, Jian Zou, Jian Zou, Jiang Wu, Weimin Li, Heping Xie, Heping Xie, Heping Xie   +19 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Improved phase field simulation of 3D multiple cracks propagation in rock materials via unified shear energy criterion

Journal of Rock Mechanics and Geotechnical Engineering
The phase-field method (PFM) has emerged as a robust tool for fracture simulation; however, applying this technique to rock materials poses significant challenges, particularly in accurately modeling the propagation of multiple cracks in the presence of ...
Susheng Wang, Sheng-Qi Yang, Qiang Zhang, Changdong Ding, Qingfu Huang, Wanqing Shen   +5 more
doaj   +1 more source