Results 41 to 50 of about 515,527 (283)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Summary of a Report on Geothermal Water Resources in Arizona: Feasibility Study [PDF]
, 1977 Published in cooperation with Arizona Water Commission and Office of Arid Lands Studies, University of Arizona.INTRODUCTION: Arid lands will undoubtedly experience increased energy stresses in the near future because of increasing internal populations ...
Norton, Denis L. +3 more
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A rotational ellipsoid model for solid Earth tide with high precision
Scientific ReportsSolid Earth tide represents the response of solid Earth to the lunar (solar) gravitational force. The yielding solid Earth due to the force has been thought to be a prolate ellipsoid since the time of Lord Kelvin, yet the ellipsoid’s geometry such as ...
Yongfeng Yang +4 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Water in the 2003 Virginia General Assembly [PDF]
, 2003 The 2003 Virginia General Assembly convened on January 8 and adjourned on February 22, with a reconvened (“veto”) session on April 2. The legislature considered 3277 measures; 1585 passed and 1692 failed. The legislature also considered amendments to the
Virginia Water Resources Research Center
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Journal of Rock Mechanics and Geotechnical EngineeringThe phase-field method (PFM) has emerged as a robust tool for fracture simulation; however, applying this technique to rock materials poses significant challenges, particularly in accurately modeling the propagation of multiple cracks in the presence of ...
Susheng Wang +5 more
doaj +1 more source
Geofluids, 2022 The laminated joints of transversely isotropic rock mass show strong discontinuity, inhomogeneity, anisotropy, and nonlinearity. This paper proposes a novel rigid block discrete element method (RB-DEM) to simulate the transversely isotropic rock mass ...
Kun Qian +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Water-Related Bills in the 2008 Virginia General Assembly [PDF]
, 2008 The 2008 Virginia General Assembly session opened January 9 and adjourned March 13. Work on the biennial state budget required a few additional days beyond the scheduled adjournment date of March 8.
Virginia Water Resources Research Center
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source