Results 41 to 50 of about 174,348 (267)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Investigation of Mechanical Characterization of Transversely Isotropic Rock Mass Based on Rigid Block Discrete Element Method

Geofluids, 2022
The laminated joints of transversely isotropic rock mass show strong discontinuity, inhomogeneity, anisotropy, and nonlinearity. This paper proposes a novel rigid block discrete element method (RB-DEM) to simulate the transversely isotropic rock mass ...
Kun Qian, Qiang Zhang, Qingxiang Meng, Qian Yin, Chun Zhu, Hangtian Song   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Investigating morphological effects of estuarine channel branching on saline water intrusion: a case study of Modaomen Estuary

Frontiers in Marine Science
Within the context of global change, morphological evolution in estuary regions and the related effects on water resource safety are key concerns for the sustainable management of river deltas.
Pu Wang, Pu Wang, Liang Hong, Liang Hong, Juli Lin, Juli Lin, Hongyue Liang, Hongyue Liang, Haiwei Li, Chao Tan, Hui Chen, Feng Liu, Feng Liu   +12 more
doaj   +1 more source

Floating wind power in deep-sea area: Life cycle assessment of environmental impacts

Advances in Applied Energy, 2023
Floating offshore wind power, an emerging technology in the offshore wind industry, has attracted increasing attention for its potential to cooperate with other renewable energies to decarbonize energy systems.
Weiyu Yuan, Jing-Chun Feng, Si Zhang, Liwei Sun, Yanpeng Cai, Zhifeng Yang, Songwei Sheng   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Archive of bacterial community in anhydrite crystals from a deep-sea basin provides evidence of past oil-spilling in a benthic environment in the Red Sea [PDF]

Biogeosciences, 2016
In deep-sea sediment, the microbes present in anhydrite crystals are potential markers of the past environment. In the Atlantis II Deep, anhydrite veins were produced by mild mixture of calcium-rich hydrothermal solutions and sulfate in the bottom water,
Y. Wang, T. G. Li, M. Y. Wang, Q. L. Lai, J. T. Li, Z. M. Gao, Z. Z. Shao, P.-Y. Qian   +7 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Capacity and Distribution of Water Stored in the Vadose Zone of the Chinese Loess Plateau

Vadose Zone Journal, 2019
Water stored in the vadose (unsaturated) zone provides the majority of water required by plants and buffers water resources; thus, it is central to understanding ecological and hydrological processes in the Chinese Loess Plateau (CLP) with its thick ...
Yuanjun Zhu, Xiaoxu Jia, Jiangbo Qiao, Andrew Binley, Robert Horton, Wei Hu, Yunqiang Wang, Ming’an Shao   +7 more
doaj   +1 more source