Results 51 to 60 of about 1,195,981 (311)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A rotational ellipsoid model for solid Earth tide with high precision

Scientific Reports
Solid Earth tide represents the response of solid Earth to the lunar (solar) gravitational force. The yielding solid Earth due to the force has been thought to be a prolate ellipsoid since the time of Lord Kelvin, yet the ellipsoid’s geometry such as ...
Yongfeng Yang, Yunfei Zhang, Qiang Liu, Xianqing Lv, Pu Huang   +4 more
doaj   +1 more source

Floating wind power in deep-sea area: Life cycle assessment of environmental impacts

Advances in Applied Energy, 2023
Floating offshore wind power, an emerging technology in the offshore wind industry, has attracted increasing attention for its potential to cooperate with other renewable energies to decarbonize energy systems.
Weiyu Yuan, Jing-Chun Feng, Si Zhang, Liwei Sun, Yanpeng Cai, Zhifeng Yang, Songwei Sheng   +6 more
doaj   +1 more source

Oceanographic drivers of deep-sea coral species distribution and community assembly on seamounts, islands, atolls, and reefs within the Phoenix Islands Protected Area [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Auscavitch, S. R., Deere, M. C., Keller, A. G., Rotjan, R. D., Shank, T. M., & Cordes, E.
Auscavitch, Steven R., Cordes, Erik E., Deere, Mary C., Keller, Abigail G., Rotjan, Randi, Shank, Timothy M.   +5 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Investigating morphological effects of estuarine channel branching on saline water intrusion: a case study of Modaomen Estuary

Frontiers in Marine Science
Within the context of global change, morphological evolution in estuary regions and the related effects on water resource safety are key concerns for the sustainable management of river deltas.
Pu Wang, Pu Wang, Liang Hong, Liang Hong, Juli Lin, Juli Lin, Hongyue Liang, Hongyue Liang, Haiwei Li, Chao Tan, Hui Chen, Feng Liu, Feng Liu   +12 more
doaj   +1 more source

Archive of bacterial community in anhydrite crystals from a deep-sea basin provides evidence of past oil-spilling in a benthic environment in the Red Sea [PDF]

Biogeosciences, 2016
In deep-sea sediment, the microbes present in anhydrite crystals are potential markers of the past environment. In the Atlantis II Deep, anhydrite veins were produced by mild mixture of calcium-rich hydrothermal solutions and sulfate in the bottom water,
Y. Wang, T. G. Li, M. Y. Wang, Q. L. Lai, J. T. Li, Z. M. Gao, Z. Z. Shao, P.-Y. Qian   +7 more
doaj   +1 more source

Potential impact of climate change on improved and unimproved water supplies in Africa [PDF]

, 2010
With significant climate change predicted in Africa over the next century, this chapter explores a key question: how will rural water supplies in Africa be affected? Approximately 550 million people in Africa live in rural communities and are reliant on
Bonsor, Helen C., Calow, Roger C., MacDonald, Alan M.   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Physiological drought responses improve predictions of live fuel moisture dynamics in a Mediterranean forest. [PDF]

, 2018
The moisture content of live fuels is an important determinant of forest flammability. Current approaches for modelling live fuel moisture content typically focus on the use of drought indices.
Arteaga López, Carles, Hedo, Javier, Nolan, Rachael H., Resco de Dios, Víctor, Sugai, Tetsuto   +4 more
core   +2 more sources