Results 61 to 70 of about 1,193,111 (325)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Investigating morphological effects of estuarine channel branching on saline water intrusion: a case study of Modaomen Estuary

Frontiers in Marine Science
Within the context of global change, morphological evolution in estuary regions and the related effects on water resource safety are key concerns for the sustainable management of river deltas.
Pu Wang, Pu Wang, Liang Hong, Liang Hong, Juli Lin, Juli Lin, Hongyue Liang, Hongyue Liang, Haiwei Li, Chao Tan, Hui Chen, Feng Liu, Feng Liu   +12 more
doaj   +1 more source

Archive of bacterial community in anhydrite crystals from a deep-sea basin provides evidence of past oil-spilling in a benthic environment in the Red Sea [PDF]

Biogeosciences, 2016
In deep-sea sediment, the microbes present in anhydrite crystals are potential markers of the past environment. In the Atlantis II Deep, anhydrite veins were produced by mild mixture of calcium-rich hydrothermal solutions and sulfate in the bottom water,
Y. Wang, T. G. Li, M. Y. Wang, Q. L. Lai, J. T. Li, Z. M. Gao, Z. Z. Shao, P.-Y. Qian   +7 more
doaj   +1 more source

Potential impact of climate change on improved and unimproved water supplies in Africa [PDF]

, 2010
With significant climate change predicted in Africa over the next century, this chapter explores a key question: how will rural water supplies in Africa be affected? Approximately 550 million people in Africa live in rural communities and are reliant on
Bonsor, Helen C., Calow, Roger C., MacDonald, Alan M.   +2 more
core  

Putative fishery-induced changes in biomass and population size structures of demersal deep-sea fishes in ICES Sub-area VII, Northeast Atlantic Ocean [PDF]

, 2012
This work was supported by a series of NERC grants to the principal investigators including NE/C512961/1. The results of the early joint SAMS and IOS surveys were digitized with support from EU MAST Contract MAS2-CT920033 1993–1995, and data analyses was
Bailey, D. M., Collins, M. A., Godbold, J. A., Gordon, J. D. M., Priede, I. G., Spallek, W. A.   +5 more
core   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biogeochemistry of deep lakes in the central Alaskan Range: Completion report [PDF]

, 1976
Casper, one of the investigators, was a guest of the National Park Service as a weekend camper at the Wonder Lake Campground within Mount McKinley National Park. On the next visit to this campground for the same purpose, Mr.
Casper, Lawrence, LaPerriere, Jacqueline
core  

Birth, life and death of the Pannonian Lake [PDF]

, 1990
The Miocene-Pliocene Pannonian Lake formed in an extensional basin system behind the compressional arc of the Carpathians. Its size and depth were comparable to those of the Caspian Sea.
Kázmér, Miklós
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source