Results 61 to 70 of about 1,195,981 (311)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Biogeochemistry of deep lakes in the central Alaskan Range: Completion report [PDF]
, 1976 Casper, one of the investigators, was a guest of the National Park Service as a weekend camper at the Wonder Lake Campground within Mount McKinley National Park. On the next visit to this campground for the same purpose, Mr.
Casper, Lawrence, LaPerriere, Jacqueline
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Capacity and Distribution of Water Stored in the Vadose Zone of the Chinese Loess Plateau
Vadose Zone Journal, 2019 Water stored in the vadose (unsaturated) zone provides the majority of water required by plants and buffers water resources; thus, it is central to understanding ecological and hydrological processes in the Chinese Loess Plateau (CLP) with its thick ...
Yuanjun Zhu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Glacial Processes and Their Relationship to Streamflow Flute Glacier, Alaska [PDF]
, 1972 Flute Glacier is located at the head of the South Fork of Eagle River, Alaska, about twenty air-miles east northeast of Anchorage. It is a small north-facing glacier, approximately two miles long and half a mile wide, situated in a deep glacial ...
Long, William E.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Mechanical behaviors and rupture processes of a typical granitic stratum
Journal of Rock Mechanics and Geotechnical EngineeringGranitic veins (GVs) have a significant influence on the mechanical responses of tunnels excavated in granitic strata. Distinguishing the mechanical properties of host granites (HGs), GVs and vein-granite interfaces (VGIs) is critical.
Xiaofang Nie +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source