Results 71 to 80 of about 4,914 (204)

Cerebral effects of cold reperfusion after hypothermic circulatory arrest [PDF]

, 2001
Objectives: This study was undertaken to explore whether an interval of cold reperfusion can improve cerebral outcome after prolonged hypothermic circulatory arrest.
McCullough, Jock, Bodian, Carol, Donald Weisz, Jock McCullough, David Wolfe, Howard Shiang, Ehrlich, Marek P., Griepp, Randall B., Randall B. Griepp, Wolfe, David, Weisz, Donald, Ning Zhang, Shiang, Howard, Marek P. Ehrlich, Carol Bodian, Zhang, Ning   +15 more
core   +1 more source

Changes in near infrared spectroscopy during deep hypothermic circulatory arrest

Annals of Cardiac Anaesthesia, 2009
Monitoring cerebral oxygenation with near infrared spectroscopy may identify periods of cerebral desaturation and thereby the patients at risk for perioperative neurocognitive issues.
Tobias Joseph, Russo Pierantonio, Russo JoAnne   +2 more
doaj  

Deep hypothermic circulatory arrest.

Annals of cardiothoracic surgery, 2013
Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes,
Bulat A, Ziganshin, John A, Elefteriades
openaire   +1 more source

Preclinical 1H MRS Study of a Porcine Model Shows Evidence and Mechanisms for Acute Neuronal Injury in Neonatal Cardiopulmonary Bypass (CPB) Surgery

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 557-567, August 2026.
ABSTRACT Purpose Congenital heart disease affects 1% of US births, with some infants requiring cardiothoracic surgery under cardiopulmonary bypass (CPB). Optimal surgical parameters to minimize neuronal injury are unknown. We used serial 1H MRS in a neonatal CPB porcine model to assess acute neuronal damage and associated injury mechanisms.
Aaron Omon, Meng Gu, Ralph Hurd, Kirk Riemer, Frank Hanley, Daniel Spielman   +5 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Immune Dysregulation in Branched Chain Organic Acidemias

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Organic acidemias (OAs) are a group of inherited disorders, most commonly caused by defects in mitochondrial enzymes involved in amino acid and fatty acid metabolism. While they characteristically present with metabolic and neurological crises, growing evidence reveals a significant burden of chronic immune dysregulation in some disorders and ...
Abdul L. Shakerdi, Jack Drda, Justin A. Dutta, Jerry Vockley   +3 more
wiley   +1 more source

Electroencephalography as a tool to predict cerebral oxygen metabolism during deep-hypothermic circulatory arrest in neonates with critical congenital heart disease. [PDF]

, 2023
OBJECTIVES: Recent research suggests that increased cerebral oxygen use during surgical intervention for neonates with congenital heart disease may play a role in the development of postoperative white matter injury.
Ranieri, Nicolina, Jacobwitz, Marin, Laurent, Gerard H, Mavroudis, Constantine D, Massey, Shavonne L, Lynch, Jennifer M, Licht, Daniel J, Ko, Tiffany S, Mensah-Brown, Kobina G, Nicolson, Susan C, Gaynor, J William, Baker, Wesley B   +11 more
core  

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Preoperative risk-of-death prediction model in heart surgery with deep hypothermic circulatory arrest in the neonate [PDF]

, 2000
Objective: Our goal was to generate a preoperative risk-of-death prediction model in selected neonates with congenital heart disease undergoing surgery with deep hypothermic circulatory arrest.
Gaynor, J.William, McGaurn, Susan A., Norwood, William I., Spray, Thomas L., Wernovsky, Gil, Jacobs, Marshall L., Murphy, John D., Clancy, Robert R., Goin, James E.   +8 more
core   +1 more source

Rationale for implementation of warm cardiac surgery in pediatrics

Frontiers in Pediatrics, 2016
Cardiac surgery was developed thanks to the introduction of hypothermia and cardiopulmonary bypass in the early 1950s. The deep hypothermia protective effect has been essential to circulatory arrest complex cases repair.
Yves eDurandy
doaj   +1 more source