Results 51 to 60 of about 820,067 (303)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Deep Neural Networks for Form-Finding of Tensegrity Structures
Mathematics, 2022 Analytical paradigms have limited conventional form-finding methods of tensegrities; therefore, an innovative approach is urgently needed. This paper proposes a new form-finding method based on state-of-the-art deep learning techniques.
Seunghye Lee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Programming Historian, 2022 This is the first of a two-part lesson introducing deep learning based computer vision methods for humanities research. Using a dataset of historical newspaper advertisements and the fastai Python library, the lesson walks through the pipeline of ...
Daniel van Strien +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Programming Historian, 2022 This is the second of a two-part lesson introducing deep learning based computer vision methods for humanities research. This lesson digs deeper into the details of training a deep learning based computer vision model.
Daniel van Strien +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Scientific ReportsEarly and accurate detection of sugarcane leaf diseases is critical for improving crop productivity and reducing economic losses in the agricultural sector. Timely interventions enable sustainable crop management and better resource use.
Jannatul Mauya +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Alzheimer’s Research & TherapyBackground The use of polygenic risk scores (PRS) for predicting disease risk in Japanese populations, particularly for dementia and related phenotypes, remains markedly unexplored.
Misato Kaishima +6 more
doaj +1 more source