Results 71 to 80 of about 549,628 (266)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Experimental observation on the seismic performance of reinforced concrete columns with a well-confined plastic hinge region

Scientific Reports
Seismic performance evaluation was conducted on eight circular reinforced concrete columns. Key design parameters for the columns included the number of longitudinal reinforcements, yield strength of reinforcements, vertical spacing of spirals, aspect ...
Do Hyung Lee, Sanh N. Tra, Dong Joo Kim, Kihak Lee   +3 more
doaj   +1 more source

A Classifier Based on K-Nearest Neighbors Using Weighted Summation of Reconstruction Errors [PDF]

مجله مدل سازی در مهندسی
In this paper, a classifier is introduced based on the nearest neighbor classifier and the reconstruction error for data classification. In the proposed method, first, K nearest data points (neighbors) from each category in the training data are ...
Rassoul Hajizadeh, Mohammad Ali Hosseinzadeh   +1 more
doaj   +1 more source

Generalization in Deep Learning

, 2022
Published by Cambridge University Press.
Kawaguchi, Kenji, Bengio, Yoshua, Kaelbling, Leslie Pak   +2 more
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Predictive Modeling for Fetal Health: A Comparative Study of PCA, LDA, and KPCA for Dimensionality Reduction

IEEE Access
Pregnancy complications significantly impact maternal and fetal health, requiring accurate and timely diagnostic methods for life-saving interventions.
Ariana Deyaneira Jimenez-Narvaez, Victor David Casa Vaca, Jonathan Javier Loor-Duque, Isidro Rafael Amaro Martin, Ivan Galo Reyes-Chacon, Paulina Vizcaino, Manuel Eugenio Morocho-Cayamcela   +6 more
doaj   +1 more source

Deep learning? What deep learning?

South African Journal of Higher Education, 2003
In teaching generally over the past twenty years, there has been a move towards teaching methods that encourage deep, rather than surface approaches to learning. The reason for this being that students, who adopt a deep approach to learning are considered to have learning outcomes of a better quality and desirability than those who adopt a surface ...
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source