Results 81 to 90 of about 8,736,056 (314)

Deep Learning With DAGs

SSRN Electronic Journal
Social science theories often postulate systems of causal relationships among variables, which are commonly represented using directed acyclic graphs (DAGs). As non-parametric causal models, DAGs require no assumptions about the functional form of the hypothesized relationships.
Sourabh Balgi, Adel Daoud, Jose M. Peña, Geoffrey T. Wodtke, Jesse Zhou   +4 more
openaire   +3 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Deep Learning at Alibaba [PDF]

Proceedings of the Twenty-Sixth International Joint Conference on Artificial Intelligence, 2017
In this talk, I will focus on the applications and the latest development of deep learning technologies at Alibaba. More specifically, I will discuss (a) how to handle high dimensional data in DNN and its application to recommender system, (b) the development of deep learning models for transfer learning and its application to multimedia data analysis,
openaire   +1 more source

Unlocking stroke prediction: Harnessing projection-based statistical feature extraction with ML algorithms

Heliyon
Non-communicable diseases, such as cardiovascular disease, cancer, chronic respiratory diseases, and diabetes, are responsible for approximately 71% of all deaths worldwide.
Saad Sahriar, Sanjida Akther, Jannatul Mauya, Ruhul Amin, Md Shahajada Mia, Sabba Ruhi, Md Shamim Reza   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Interpreting Deep Learning Models

, 2020
Model interpretability is a requirement in many applications in which crucial decisions are made by users relying on a model's outputs. The recent movement for “algorithmic fairness” also stipulates explainability, and therefore interpretability of ...
Liu, Xuan
core  

Correlation Between Depression-Associated Genes and Cancer Types: Predicting Cancer Based on Mutation Frequencies

IEEE Access
This study examines the potential interconnection between genetic mutations frequently observed in various types of cancer and depression, aiming to elucidate shared genetic factors that may influence the etiology and treatment of both conditions ...
Fernando Patricio Carranco-Avila, Clayanela Zambrano-Caicedo, Jonathan Javier Loor-Duque, Ariana Deyaneira Jimenez-Narvaez, Ivan Galo Reyes-Chacon, Paulina Vizcaino, Isidro Rafael Amaro Martin, Manuel Eugenio Morocho-Cayamcela   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Experimental observation on the seismic performance of reinforced concrete columns with a well-confined plastic hinge region

Scientific Reports
Seismic performance evaluation was conducted on eight circular reinforced concrete columns. Key design parameters for the columns included the number of longitudinal reinforcements, yield strength of reinforcements, vertical spacing of spirals, aspect ...
Do Hyung Lee, Sanh N. Tra, Dong Joo Kim, Kihak Lee   +3 more
doaj   +1 more source