Results 121 to 130 of about 1,508,361 (330)
What do we know about reading and spelling in shallow orthographies?
Revista de Investigación en LogopediaReading and spelling research has traditionally been centred on English, despite its significant differences from other European orthographies. This anglocentric focus raises questions about the generalisability of reading theories to alphabetic ...
Xenia Schmalz
doaj +1 more source
Deep Reads: Strands in the History of Molecular Genetics
PLoS Genetics, 2014 The history of molecular genetics, its precursors and descendants, is rich in events and colorful characters intertwining through the tumultuous history of the mid20th century. In this second iteration of ‘‘Deep Reads,’’ I try to trace selected strands in the ancestry of the field as told in histories, biographies, and memoirs, some of which I have ...
openaire +4 more sources
Research on English Reading Teaching in High Schools from the Perspective of Deep Learning
, 2023 Yu He
openalex +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Questioning Optimization Strategies of High School English Reading Classroom based on Deep Learning
, 2023 Zulin Liu, Xiying Fan
openalex +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source