Results 81 to 90 of about 1,876 (209)
Theological Librarianship, 2014 This essay makes a case for the value of slow or deep reading. Inspired by the Slow Food movement it seeks to apply their principles to reading. It begins by exploring the meaning of information and how like food, information has come to be regarded as
Matthew J Ostercamp
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
دراسات: العلوم التربوية, 2021 This study aims at constructing a diagnostic scale to distinguish between surface and deep dyslexia in the light of the dual-route model, verifying its psychometric characteristics and detecting the differences in its lexical route and non-lexical route
Mayada Al-Natour, Faten Al-Mashayek
doaj
Research on the evaluation method of English textbook readability based on the TextCNN model and its application in teaching design [PDF]
PeerJ Computer ScienceEnglish is a world language, and the ability to use English plays an important role in the improvement of college students’ comprehensive quality and career development.
Ying Qin, Azeem Irshad
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Deep Reads: Strands in the History of Molecular Genetics
PLoS Genetics, 2014 The history of molecular genetics, its precursors and descendants, is rich in events and colorful characters intertwining through the tumultuous history of the mid20th century. In this second iteration of ‘‘Deep Reads,’’ I try to trace selected strands in the ancestry of the field as told in histories, biographies, and memoirs, some of which I have ...
openaire +4 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
BUDAYA BACA SISWA SMP DI ERA INTERNET
Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya, 2011 The Internet is believed to have changed reading habits: deep reading has shifted due to the easy access on the Net. This research is intended to unravel the reading behavior of Junior High School students in the Municipality of Malang.
Nurhadi .
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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