Results 171 to 180 of about 103,225 (263)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Elucidating the mechanism of thiosulfate oxidation by a novel two-component system SulRS in deep-sea <i>Campylobacterota</i>. [PDF]

iScience
Zhong Y, Wang S, Wei G, Gao X, Yang C, Nie X, Alain K, Hong R, Zeng X, Shao Z, Jiang L.   +10 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Genomic insights into a versatile deep-sea methanotroph constituting the rare biosphere of a Brazilian carbonate mound complex. [PDF]

mSystems
Butarelli ACdA, Nakamura FM, Vilela Peres F, Modolon da Silva F, Bendia AG, Basti R, Mahiques MMd, Sumida PYG, Pellizari VH.   +8 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Deep-sea mining: Superficial riches, deep hidden costs

Sumaila UR, Alam L, Pradhoshini K, Flint R, Singh P, Billon PL, Mosnier F, Amon D, Abdallah P, Aheto D, Alger J, Anna Z, Barnes C, Fritsch D, Giron A, Gjerde K, Hilmi N, Karuaihe S, Levin L, Mohammed, Sukhdev P, Tudhope A, Thiele T, Villasante S, Wilson M.   +24 more
europepmc   +1 more source

Putative promiscuous symbionts in deep-sea corals and crinoids may contribute to nitrogen cycling. [PDF]

Microbiome
Modolon F, N Garritano A, J Hill L, Duarte G, Bendia A, de Moura R, Pellizari V, Thomas T, Peixoto RS.   +8 more
europepmc   +1 more source

Phosphorescence in Deep-Sea Animals [PDF]

Science, 1900
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Microbial community structure and metabolic characteristics in sediments from five different deep-sea trenches. [PDF]

Front Microbiol
Xiao Y, Liu H, Wu Z, Li X, Jing H.
europepmc   +1 more source