Results 191 to 200 of about 136,601 (268)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Deep-sea gas hydrate mounds and chemosynthetic fauna discovered at 3640 m on the Molloy Ridge, Greenland Sea. [PDF]

Nat Commun
Panieri G, Copley JT, Linse K, Nye V, Ramirez-Llodra E, Argentino C, Ferré B, Arctic Deep - Extreme24 consortium, Rogers AD.   +8 more
europepmc   +1 more source

Dinoflagellate Cysts in Deep-Sea Cores from DSDP Site 372, East Menorca Rise

, 1978
Domenico Corradini
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Seeing the unseen: problematic narratives and the microbial worlds of the deep-sea. [PDF]

Hist Philos Life Sci
Brandt TJ.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Diverse quorum sensing systems regulate microbial communication and biogeochemical processes in deep-sea cold seeps. [PDF]

Microbiome
Peng J, Liu X, Wang J, Meng N, Cai R, Peng Y, Han Y, Liao J, Li C, Rubin-Blum M, Ma Q, Dong X.   +11 more
europepmc   +1 more source

Do deep-sea nematodes show a positive latitudinal gradient of species diversity? The potential role of depth

, 2001
MA Rex, CT Stuart, RJ Etter
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Mutualism on the deep-sea floor: a novel shell-forming sea anemone in symbiosis with a hermit crab. [PDF]

R Soc Open Sci
Yoshikawa A, Izumi T, Kanki T, Moritaki T, Kitajima M, Ohtsuchi N, Kimura T, Gou Y, Hattori R, Yumiba M, Shirai K, Mitchell ML, Fujita T, Yanagi K.   +13 more
europepmc   +1 more source